Acupuncture Stimulation Alleviates Corticosterone-Induced Impairments of Spatial Memory and Cholinergic Neurons in Rats
Joint Authors
Shim, Insop
Lee, Hyejung
Lee, Bombi
Sur, Bong-Jun
Kwon, Sunoh
Jung, Euntaek
Hahm, Dae-Hyun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-15
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The purpose of this study was to examine whether acupuncture improves spatial cognitive impairment induced by repeated corticosterone (CORT) administration in rats.
The effect of acupuncture on the acetylcholinergic system was also investigated in the hippocampus.
Male rats were subcutaneously injected with CORT (5 mg/kg) once daily for 21 days.
Acupuncture stimulation was performed at the HT7 (Sinmun) acupoint for 5 min before CORT injection.
HT7 acupoint is located at the end of transverse crease of ulnar wrist of forepaw.
In CORT-treated rats, reduced spatial cognitive function was associated with significant increases in plasma CORT level (+36%) and hippocampal CORT level (+204%) compared with saline-treated rats.
Acupuncture stimulation improved the escape latency for finding the platform in the Morris water maze.
Consistently, the acupuncture significantly alleviated memory-associated decreases in cholinergic immunoreactivity and mRNA expression of BDNF and CREB in the hippocampus.
These findings demonstrate that stimulation of HT7 acupoint produced significant neuroprotective activity against the neuronal impairment and memory dysfunction.
American Psychological Association (APA)
Lee, Bombi& Sur, Bong-Jun& Kwon, Sunoh& Jung, Euntaek& Shim, Insop& Lee, Hyejung…[et al.]. 2011. Acupuncture Stimulation Alleviates Corticosterone-Induced Impairments of Spatial Memory and Cholinergic Neurons in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-992516
Modern Language Association (MLA)
Lee, Bombi…[et al.]. Acupuncture Stimulation Alleviates Corticosterone-Induced Impairments of Spatial Memory and Cholinergic Neurons in Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-992516
American Medical Association (AMA)
Lee, Bombi& Sur, Bong-Jun& Kwon, Sunoh& Jung, Euntaek& Shim, Insop& Lee, Hyejung…[et al.]. Acupuncture Stimulation Alleviates Corticosterone-Induced Impairments of Spatial Memory and Cholinergic Neurons in Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-992516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992516