Acute and Chronic Administrations of Rheum palmatum Reduced the Bioavailability of Phenytoin in Rats: A New Herb-Drug Interaction
Joint Authors
Juang, Shin-Hun
Chi, Ying-Chang
Chao, Pei-Dawn Lee
Hou, Yu-Chi
Chui, Wai Keung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The rhizome of Rheum palmatum (RP) is a commonly used herb in clinical Chinese medicine.
Phenytoin (PHT) is an antiepileptic with narrow therapeutic window.
This study investigated the acute and chronic effects of RP on the pharmacokinetics of PHT in rat.
Rats were orally administered with PHT (200 mg/kg) with and without RP decoction (single dose and seven doses of 2 g/kg) in a crossover design.
The serum concentrations of PHT, PHT glucuronide (PHT-G), 4-hydroxyphenytoin (HPPH), and HPPH glucuronide (HPPH-G) were determined by HPLC method.
Cell line models were used to identify the underlying mechanisms.
The results showed that coadministration of single dose or multiple doses of RP significantly decreased the Cmax and AUC0-t as well as the K10 of PHT, PHT-G, HPPH, and HPPH-G.
Cell line studies revealed that RP significantly induced the P-gp-mediated efflux of PHT and inhibited the MRP-2-medicated transport of PHT and HPPH.
In conclusion, acute and chronic coadministrations of RP markedly decreased the oral bioavailability of PHT via activation of P-gp, although the MRP-2-mediated excretion of PHT was inhibited.
It is recommended that caution should be exercised during concurrent use of RP and PHT.
American Psychological Association (APA)
Chi, Ying-Chang& Juang, Shin-Hun& Chui, Wai Keung& Hou, Yu-Chi& Chao, Pei-Dawn Lee. 2012. Acute and Chronic Administrations of Rheum palmatum Reduced the Bioavailability of Phenytoin in Rats: A New Herb-Drug Interaction. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992553
Modern Language Association (MLA)
Chi, Ying-Chang…[et al.]. Acute and Chronic Administrations of Rheum palmatum Reduced the Bioavailability of Phenytoin in Rats: A New Herb-Drug Interaction. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-992553
American Medical Association (AMA)
Chi, Ying-Chang& Juang, Shin-Hun& Chui, Wai Keung& Hou, Yu-Chi& Chao, Pei-Dawn Lee. Acute and Chronic Administrations of Rheum palmatum Reduced the Bioavailability of Phenytoin in Rats: A New Herb-Drug Interaction. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992553
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992553