Kappa-Opioid Receptors in the Caudal Nucleus Tractus Solitarius Mediate 100 Hz Electroacupuncture-Induced Sleep Activities in Rats
Joint Authors
Cheng, Chiung-Hsiang
Yi, Pei-Lu
Chang, Han-Han
Tsai, Yi-Fong
Chang, Fang-Chia
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Previous results demonstrated that 10 Hz electroacupuncture (EA) of Anmian acupoints in rats during the dark period enhances slow wave sleep (SWS), which involves the induction of cholinergic activity in the caudal nucleus tractus solitarius (NTS) and subsequent activation of opioidergic neurons and μ-receptors.
Studies have shown that different kinds of endogenous opiate peptides and receptors may mediate the consequences of EA with different frequencies.
Herein, we further elucidated that high-frequency (100 Hz)-EA of Anmian enhanced SWS during the dark period but exhibited no direct effect on rapid eye movement (REM) sleep.
High-frequency EA-induced SWS enhancement was dose-dependently blocked by microinjection of naloxone or κ-receptor antagonist (nor-binaltorphimine) into the caudal NTS, but was affected neither by μ- (naloxonazine) nor δ-receptor antagonists (natatrindole), suggesting the role of NTS κ-receptors in the high-frequency EA-induced SWS enhancement.
Current and previous results depict the opioid mechanisms of EA-induced sleep.
American Psychological Association (APA)
Cheng, Chiung-Hsiang& Yi, Pei-Lu& Chang, Han-Han& Tsai, Yi-Fong& Chang, Fang-Chia. 2012. Kappa-Opioid Receptors in the Caudal Nucleus Tractus Solitarius Mediate 100 Hz Electroacupuncture-Induced Sleep Activities in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992573
Modern Language Association (MLA)
Cheng, Chiung-Hsiang…[et al.]. Kappa-Opioid Receptors in the Caudal Nucleus Tractus Solitarius Mediate 100 Hz Electroacupuncture-Induced Sleep Activities in Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-992573
American Medical Association (AMA)
Cheng, Chiung-Hsiang& Yi, Pei-Lu& Chang, Han-Han& Tsai, Yi-Fong& Chang, Fang-Chia. Kappa-Opioid Receptors in the Caudal Nucleus Tractus Solitarius Mediate 100 Hz Electroacupuncture-Induced Sleep Activities in Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992573