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Antileukemic Potential of Momordica charantia Seed Extracts on Human Myeloid Leukemic HL60 Cells
Joint Authors
Dixit, Aparna
Soundararajan, Ramani
Prabha, Punit
Rai, Umesh
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Momordica charantia (bitter gourd) has been used in the traditional system of medicine for the treatment of various diseases.
Anticancer activity of M.
charantia extracts has been demonstrated by numerous in vitro and in vivo studies.
In the present study, we investigated the differentiation inducing potential of fractionated M.
charantia seed extracts in human myeloid HL60 cells.
We found that the HL60 cells treated with the fractionated seed extracts differentiated into granulocytic lineage as characterized by NBT staining, CD11b expression, and specific esterase activity.
The differentiation inducing principle was found to be heat-stable, and organic in nature.
The differentiation was accompanied by a downregulation of c-myc transcript, indicating the involvement of c-myc pathway, at least in part, in differentiation.
Taken together these results indicate that fractionated extracts of M.
charantia seeds possess differentiation inducing activity and therefore can be evaluated for their potential use in differentiation therapy for leukemia in combination with other inducers of differentiation.
American Psychological Association (APA)
Soundararajan, Ramani& Prabha, Punit& Rai, Umesh& Dixit, Aparna. 2012. Antileukemic Potential of Momordica charantia Seed Extracts on Human Myeloid Leukemic HL60 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992590
Modern Language Association (MLA)
Soundararajan, Ramani…[et al.]. Antileukemic Potential of Momordica charantia Seed Extracts on Human Myeloid Leukemic HL60 Cells. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-992590
American Medical Association (AMA)
Soundararajan, Ramani& Prabha, Punit& Rai, Umesh& Dixit, Aparna. Antileukemic Potential of Momordica charantia Seed Extracts on Human Myeloid Leukemic HL60 Cells. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992590
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992590