Long-Term Consumption of Platycodi Radix Ameliorates Obesity and Insulin Resistance via the Activation of AMPK Pathways
Joint Authors
Park, Jae Ho
Kim, Myung-Sunny
Hur, Haeng Jeon
Sung, Mi Jeong
Kwon, Dae Young
Yang, Hye Jeong
Lee, Chae Eun
Hwang, Jin-Taek
Kim, Hyun Jin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study was designed to evaluate the effects and mechanism of Platycodi radix, having white balloon flower (Platycodon grandiflorum for.
albiflorum (Honda) H.
Hara) on obesity and insulin resistance.
The extracts of Platycodi radix with white balloon flower were tested in cultured cells and administered into mice on a high-fat diet.
The Platycodi radix activated the AMPK/ACC phosphorylation in C2C12 myotubes and also suppressed adipocyte differentiation in 3T3-L1 cells.
In experimental animal, it suppressed the weight gain of obese mice and ameliorated obesity-induced insulin resistance.
It also reduced the elevated circulating mediators, including triglyceride (TG), T-CHO, leptin, resistin, and monocyte chemotactic protein (MCP)-1 in obesity.
As shown in C2C12 myotubes, the administration of Platycodi radix extracts also recovered the AMPK/ACC phosphorylation in the muscle of obese mice.
These results suggest that Platycodi radix with white balloon flower ameliorates obesity and insulin resistance in obese mice via the activation of AMPK/ACC pathways and reductions of adipocyte differentiation.
American Psychological Association (APA)
Lee, Chae Eun& Hur, Haeng Jeon& Hwang, Jin-Taek& Sung, Mi Jeong& Yang, Hye Jeong& Kim, Hyun Jin…[et al.]. 2012. Long-Term Consumption of Platycodi Radix Ameliorates Obesity and Insulin Resistance via the Activation of AMPK Pathways. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992623
Modern Language Association (MLA)
Lee, Chae Eun…[et al.]. Long-Term Consumption of Platycodi Radix Ameliorates Obesity and Insulin Resistance via the Activation of AMPK Pathways. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-992623
American Medical Association (AMA)
Lee, Chae Eun& Hur, Haeng Jeon& Hwang, Jin-Taek& Sung, Mi Jeong& Yang, Hye Jeong& Kim, Hyun Jin…[et al.]. Long-Term Consumption of Platycodi Radix Ameliorates Obesity and Insulin Resistance via the Activation of AMPK Pathways. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992623