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Immunomodulatory Effect of Rhaphidophora korthalsii on Natural Killer Cell Cytotoxicity
Joint Authors
Alitheen, Noorjahan Banu Mohamed
Beh, Boon Kee
Omar, Abdul Rahman
Ali, Abdul Manaf
Ho, Wan Yong
Yeap, Swee Keong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The in vivo immunomodulatory effect of ethanolic extracts from leaves of Rhaphidophora korthalsii was determined via immune cell proliferation, T/NK cell phenotyping, and splenocyte cytotoxicity of BALB/c mice after 5 consecutive days of i.p.
administration at various concentrations.
Splenocyte proliferation index, cytotoxicity, peripheral blood T/NK cell population, and plasma cytokine (IL-2 and IFN-γ) in mice were assessed on day 5 and day 15.
High concentration of extract (350 μg/mice/day for 5 consecutive days) was able to stimulate immune cell proliferation, peripheral blood NK cell population, IL-2, and IFN- γ cytokines, as well as splenocyte cytotoxicity against Yac-1 cell line.
Unlike rIL-2 which degraded rapidly, the stimulatory effect from the extract managed to last until day 15.
These results suggested the potential of this extract as an alternative immunostimulator, and they encourage further study on guided fractionation and purification to identify the active ingredients that contribute to this in vitro and in vivo immunomodulatory activity.
American Psychological Association (APA)
Yeap, Swee Keong& Omar, Abdul Rahman& Ali, Abdul Manaf& Ho, Wan Yong& Beh, Boon Kee& Alitheen, Noorjahan Banu Mohamed. 2011. Immunomodulatory Effect of Rhaphidophora korthalsii on Natural Killer Cell Cytotoxicity. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992640
Modern Language Association (MLA)
Yeap, Swee Keong…[et al.]. Immunomodulatory Effect of Rhaphidophora korthalsii on Natural Killer Cell Cytotoxicity. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-992640
American Medical Association (AMA)
Yeap, Swee Keong& Omar, Abdul Rahman& Ali, Abdul Manaf& Ho, Wan Yong& Beh, Boon Kee& Alitheen, Noorjahan Banu Mohamed. Immunomodulatory Effect of Rhaphidophora korthalsii on Natural Killer Cell Cytotoxicity. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992640