Ligustrazine Injection for Chronic Pulmonary Heart Disease: A Systematic Review and Meta-Analysis
Joint Authors
Jian-sheng, Li
Hai-feng, Wang
Yun-ping, Bai
Su-yun, Li
Xue-qing, Yu
Ya, Li
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study was intended to evaluate the efficacy and safety of ligustrazine injection for chronic pulmonary heart disease (CPHD).
Method.
Randomized controlled trials (RCTs) of clinical therapeutic studies on CPHD when using ligustrazine injection were included.
Searches were applied to the following electronic databases: the PubMed, the Cochrane Library, EMBASE, CBM, and AMED.
No language restriction was used.
All trials included were analyzed according to the criteria of the Cochrane Handbook.
Review Manager 5.0 software was used for data analysis.
Result.
34 RCTs with low methodological quality were included.
Compared to conventional medicine treatment alone, ligustrazine injection plus conventional medicine treatment showed improvement in New York Heart Association classification of clinical status (Odds ratio 0.22; 95% CI 0.17 to 0.28) and depression of pulmonary artery hypertension (weighted mean difference −4.77; 95% CI −5.85 to −3.68).
Three studies had reported adverse events.
No serious adverse effects were reported.
Conclusion.
While there is some evidence that suggests potential effectiveness of ligustrazine injection for CPHD, the results were limited by the methodological flaws of the studies.
High quality studies are needed to provide clear evidence for the future use of ligustrazine injection.
American Psychological Association (APA)
Jian-sheng, Li& Hai-feng, Wang& Yun-ping, Bai& Su-yun, Li& Xue-qing, Yu& Ya, Li. 2011. Ligustrazine Injection for Chronic Pulmonary Heart Disease: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992645
Modern Language Association (MLA)
Jian-sheng, Li…[et al.]. Ligustrazine Injection for Chronic Pulmonary Heart Disease: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992645
American Medical Association (AMA)
Jian-sheng, Li& Hai-feng, Wang& Yun-ping, Bai& Su-yun, Li& Xue-qing, Yu& Ya, Li. Ligustrazine Injection for Chronic Pulmonary Heart Disease: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992645