In Vivo Anti-Influenza Virus Activity of Japanese Herbal (Kampo) Medicine, “Shahakusan,” and Its Possible Mode of Action
Joint Authors
Hokari, Rei
Nagai, Takayuki
Yamada, Haruki
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
A Kampo medicine, Shahakusan (SHS), has been prescribed in late phase of infection that causes inflammations in the lung.
But effect of SHS on viral infection in respiratory tract has never been reported.
Objectives.
To evaluate anti-influenza virus activity of SHS and its mode of actions through immune systems.
Methods.
SHS (0.3 g/kg/day) was orally administered to BALB/c miceforupper (URI) or lower respiratory tract infection (LRI) of influenza virus A/PR/8/34.
The virus titer of nasal lavage fluid (NLF) at 5 or 2 day postinfection (p.i.) and cytokine mRNA expressions in mandibular lymph node or lung at 5 or 4 day p.i.
were evaluated for URI or LRI, respectively.
The histopathological examinations of lung tissue and NK cell activity in the splenocytes were also evaluated at 4 day p.i.
on LRI.
Results.
When SHS was administered from 7 days before to 4 days p.i.
for URI, the virus titer was significantly decreased in comparison with water-treated control, and IL-4, IL-1β, and IL-10 mRNA expression was decreased, but IL-12A mRNA expression was increased.
Administration of SHS from one day before to one day p.i.
for LRI significantly decreased the virus titer.
SHS also decreased infiltration of inflammatory cells in the bronchoalveolar spaces and damage of desquamated mucosal epithelia of bronchiole, decreased IP-10 mRNA expression, and increased NK cell activity.
Conclusion.
SHS has no direct effect on influenza virus infection but exerts antiviral effect in mice by its immunomodulating activity through action of NK cells and anti-inflammatory activity in the lung.
American Psychological Association (APA)
Hokari, Rei& Nagai, Takayuki& Yamada, Haruki. 2012. In Vivo Anti-Influenza Virus Activity of Japanese Herbal (Kampo) Medicine, “Shahakusan,” and Its Possible Mode of Action. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-992650
Modern Language Association (MLA)
Hokari, Rei…[et al.]. In Vivo Anti-Influenza Virus Activity of Japanese Herbal (Kampo) Medicine, “Shahakusan,” and Its Possible Mode of Action. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-992650
American Medical Association (AMA)
Hokari, Rei& Nagai, Takayuki& Yamada, Haruki. In Vivo Anti-Influenza Virus Activity of Japanese Herbal (Kampo) Medicine, “Shahakusan,” and Its Possible Mode of Action. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-992650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992650