Anti-Inflammatory and Anticoagulative Effects of Paeonol on LPS-Induced Acute Lung Injury in Rats
Joint Authors
Wu, Chieh-Liang
Fu, Pin-Kuei
Hsieh, Ching-Liang
Tsai, Tung-Hu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Paeonol is an active component of Moutan Cortex Radicis and is widely used as an analgesic, antipyretic, and anti-inflammatory agent in traditional Chinese medicine.
We wanted to determine the role of paeonol in treating adult respiratory distress syndrome (ARDS).
We established an acute lung injury (ALI) model in Sprague-Dawley rats, which was similar to ARDS in humans, using intratracheal administration of lipopolysaccharide (LPS).
The intraperitoneal administration of paeonol successfully reduced histopathological scores and attenuated myeloperoxidase-reactive cells as an index of polymorphonuclear neutrophils infiltration and also reduces inducible nitric oxide synthase expression in the lung tissue, at 16 h after LPS administration.
In addition, paeonol reduced proinflammatory cytokines in bronchoalveolar lavage fluid, including tumor-necrosis factor-α, interleukin-1β, interleukin-6, and plasminogen-activated inhibition factor-1.
These results indicated that paeonol successfully attenuates inflammatory and coagulation reactions to protect against ALI.
American Psychological Association (APA)
Fu, Pin-Kuei& Wu, Chieh-Liang& Tsai, Tung-Hu& Hsieh, Ching-Liang. 2012. Anti-Inflammatory and Anticoagulative Effects of Paeonol on LPS-Induced Acute Lung Injury in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992695
Modern Language Association (MLA)
Fu, Pin-Kuei…[et al.]. Anti-Inflammatory and Anticoagulative Effects of Paeonol on LPS-Induced Acute Lung Injury in Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-992695
American Medical Association (AMA)
Fu, Pin-Kuei& Wu, Chieh-Liang& Tsai, Tung-Hu& Hsieh, Ching-Liang. Anti-Inflammatory and Anticoagulative Effects of Paeonol on LPS-Induced Acute Lung Injury in Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992695