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Liuwei Dihuang Lowers Body Weight and Improves Insulin and Leptin Sensitivity in Obese Rats
Joint Authors
Wang, Yanwen
Perry, Benjamin
Saleh, Tarek M.
Zhang, Junzeng
Sun, Changhao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study was aimed at investigating the efficacy and mechanism(s) of action of a Chinese herbal formulation, Liuwei Dihuang (LWDH), as a prospective natural weight-lowering product.
Following a 2-week acclimation period, 48 obesity-prone (OP-CD) rats were divided into 4 groups (n=12 each).
One group served as a positive control for obesity (OP), while the other 3 were challenged twice daily by oral gavage with total daily dosages of 500, 1500, or 3500 mg/kg BW LWDH, respectively, for 10 weeks.
One group (n=12) of obesity-resistant (OR-CD) rats served as the normal control group.
All rats were fed the same AIN-93G diet modified to contain 60% energy from fat.
The highest LWDH dose significantly reduced body weight during the last 4 weeks of treatment.
Food intake was reduced beginning in week 2.
The high LWDH dose lowered serum triglyceride (TG) and nonesterified fatty acid (NEFA) levels and body fat.
Both the high and medium doses also lowered serum leptin and insulin levels.
Liver function testing revealed no adverse side effects under the current experimental conditions.
The results of the present study suggest that LWDH has potential as a preventive or therapeutic natural product against overweight and obesity.
American Psychological Association (APA)
Perry, Benjamin& Zhang, Junzeng& Sun, Changhao& Saleh, Tarek M.& Wang, Yanwen. 2011. Liuwei Dihuang Lowers Body Weight and Improves Insulin and Leptin Sensitivity in Obese Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992709
Modern Language Association (MLA)
Perry, Benjamin…[et al.]. Liuwei Dihuang Lowers Body Weight and Improves Insulin and Leptin Sensitivity in Obese Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992709
American Medical Association (AMA)
Perry, Benjamin& Zhang, Junzeng& Sun, Changhao& Saleh, Tarek M.& Wang, Yanwen. Liuwei Dihuang Lowers Body Weight and Improves Insulin and Leptin Sensitivity in Obese Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992709
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992709