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Coral-Associated Bacteria as a Promising Antibiofilm Agent against Methicillin-Resistant and -Susceptible Staphylococcus aureus Biofilms
Joint Authors
Gowrishankar, Shanmugaraj
Duncun Mosioma, Nyagwencha
Karutha Pandian, Shunmugiah
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-04
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The current study deals with the evaluation of two coral-associated bacterial (CAB) extracts to inhibit the biofilm synthesis in vitro as well as the virulence production like hemolysin and exopolysaccharide (EPS), and also to assess their ability to modify the adhesion properties, that is cell surface hydrophobicity (CSH) of methicillin-resistant (MRSA) and -susceptible Staphylococcus aureus (MSSA).
Out of nine CAB screened, the ethyl acetate extract of CAB-E2 (Bacillus firmus) and CAB-E4 (Vibrio parahemolyticus) have shown excellent antibiofilm activity against S.
aureus.
CAB-E2 reduced the production of EPS (57–79%) and hemolysin (43–70%), which ultimately resulted in the significant inhibition of biofilms (80–87%) formed by both MRSA and MSSA.
Similarly, CAB-E4 was also found to decrease the production of EPS (43–57%), hemolysin (43–57%) and biofilms (80–85%) of test pathogens.
CLSM analysis also proved the antibiofilm efficacy of CAB extracts.
Furthermore, the CAB extracts strongly decreased the CSH of S.
aureus.
Additionally, FT-IR analysis of S.
aureus treated with CAB extracts evidenced the reduction in cellular components compared to their respective controls.
Thus, the present study reports for the first time, B.
firmus—a coral-associated bacterium, as a promising source of antibiofilm agent against the recalcitrant biofilms formed by multidrug resistant S.
aureus.
American Psychological Association (APA)
Gowrishankar, Shanmugaraj& Duncun Mosioma, Nyagwencha& Karutha Pandian, Shunmugiah. 2012. Coral-Associated Bacteria as a Promising Antibiofilm Agent against Methicillin-Resistant and -Susceptible Staphylococcus aureus Biofilms. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-992722
Modern Language Association (MLA)
Gowrishankar, Shanmugaraj…[et al.]. Coral-Associated Bacteria as a Promising Antibiofilm Agent against Methicillin-Resistant and -Susceptible Staphylococcus aureus Biofilms. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-992722
American Medical Association (AMA)
Gowrishankar, Shanmugaraj& Duncun Mosioma, Nyagwencha& Karutha Pandian, Shunmugiah. Coral-Associated Bacteria as a Promising Antibiofilm Agent against Methicillin-Resistant and -Susceptible Staphylococcus aureus Biofilms. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-992722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992722