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Hepatoprotective Potential of Caesalpinia crista against Iron-Overload-Induced Liver Toxicity in Mice
Joint Authors
Mandal, Nripendranath
Sarkar, Rhitajit
Hazra, Bibhabasu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The present study was carried out to evaluate the ameliorating effect of Caesalpinia crista Linn.
(CCME) extract on iron-overload-induced liver injury.
Iron overload was induced by intraperitoneal administration of iron dextran into mice.
CCME attenuated the percentage increase in liver iron and serum ferritin levels when compared to control group.
CCME also showed a dose-dependent inhibition of lipid peroxidation, protein oxidation, and liver fibrosis.
The serum enzyme markers were found to be less, whereas enhanced levels of liver antioxidant enzymes were detected in CCME-treated group.
In presence of CCME, the reductive release of ferritin iron was increased significantly.
Furthermore, CCME exhibited DPPH radical scavenging and protection against Fe2+-mediated oxidative DNA damage.
The current study confirmed the hepatoprotective effect of CCME against the model hepatotoxicant iron overload and the activity is likely related to its potent antioxidant and iron-chelating property.
American Psychological Association (APA)
Sarkar, Rhitajit& Hazra, Bibhabasu& Mandal, Nripendranath. 2012. Hepatoprotective Potential of Caesalpinia crista against Iron-Overload-Induced Liver Toxicity in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992752
Modern Language Association (MLA)
Sarkar, Rhitajit…[et al.]. Hepatoprotective Potential of Caesalpinia crista against Iron-Overload-Induced Liver Toxicity in Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-992752
American Medical Association (AMA)
Sarkar, Rhitajit& Hazra, Bibhabasu& Mandal, Nripendranath. Hepatoprotective Potential of Caesalpinia crista against Iron-Overload-Induced Liver Toxicity in Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992752
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992752