Shengjie Tongyu Granule Inhibits Vascular Remodeling in ApoE-Gene-Knockout Mice
Joint Authors
Chen, Min
Cheng, Wenli
Shi, Zaixiang
Tatsukazu, Nishihara
Zhou, Tongliang
Li, Hong
Guo, Jian
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The aim of the present paper was to investigate the effect of Shengjie Tongyu granule on vascular remodeling in atherosclerotic mice and the relevant underlying mechanism.
Sixty male ApoE-gene-knockout mice, fed a high-fat diet from 6 weeks of age, were randomized into a Shengjie Tongyu granule group (4.00 g/kg/d), a simvastatin group (9.01 mg/kg/d), and a control group (normal saline: 0.2 mL/d).
At the ages of 30 and 40 weeks, we sacrificed the mice for various measurements.
The results show that treatment with Shengjie Tongyu granule and simvastatin significantly decreased lumen and plaque areas in the aortic root at 30 and 40 weeks of age, decreased grade II elastic fiber lesions in the ascending aorta at 30 weeks of age, and decreased both grade II and III lesions at 40 weeks of age, compared to controls.
The content of superoxide anions, and expression of MOMA-2, plasma ICAM-1, and NFκB p50 in 30- and 40-week-old mice in the Shengjie Tongyu granule and simvastatin groups were also significantly reduced compared to the control group.
In conclusion, Shengjie Tongyu granule has a clear inhibitory effect on vascular remodeling and on inflammatory pathways in ApoE-gene-knockout mice.
American Psychological Association (APA)
Chen, Min& Cheng, Wenli& Shi, Zaixiang& Tatsukazu, Nishihara& Zhou, Tongliang& Li, Hong…[et al.]. 2012. Shengjie Tongyu Granule Inhibits Vascular Remodeling in ApoE-Gene-Knockout Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-992753
Modern Language Association (MLA)
Chen, Min…[et al.]. Shengjie Tongyu Granule Inhibits Vascular Remodeling in ApoE-Gene-Knockout Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-992753
American Medical Association (AMA)
Chen, Min& Cheng, Wenli& Shi, Zaixiang& Tatsukazu, Nishihara& Zhou, Tongliang& Li, Hong…[et al.]. Shengjie Tongyu Granule Inhibits Vascular Remodeling in ApoE-Gene-Knockout Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-992753
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992753