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Copaiba Oil: An Alternative to Development of New Drugs against Leishmaniasis
Joint Authors
Ueda-Nakamura, Tânia
dos Santos, Adriana Oliveira
Dias Filho, Benedito Prado
Veiga-Junior, Valdir F.
Nakamura, Celso Vataru
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Leishmaniasis is a neglected disease that is increasing globally at an alarming rate.
Glucantime has been the therapy of choice for more than 50 years.
A recent study reported the antileishmanial activity of copaiba oil against Leishmania amazonensis.
These results led us to investigate morphological and ultrastructural changes in L.
amazonensis treated with copaiba oil, using electron microscopy and flow cytometry to assess specific organelles as targets for copaiba oil.
In the promastigote and axenic amastigote forms, this copaiba oil caused notable morphological and ultrastructural changes, including extensive mitochondrial damage and denaturation of the plasma membrane.
Copaiba oil treatment also induced a decrease in Rh123 fluorescence, suggesting interference with the mitochondrial membrane potential and loss of cell viability with an increase in plasma membrane permeability, as observed by flow cytometry after staining with propidium iodide.
In conclusion, copaiba oil could be exploited for the development of new antileishmanial drugs.
American Psychological Association (APA)
dos Santos, Adriana Oliveira& Ueda-Nakamura, Tânia& Dias Filho, Benedito Prado& Veiga-Junior, Valdir F.& Nakamura, Celso Vataru. 2011. Copaiba Oil: An Alternative to Development of New Drugs against Leishmaniasis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992754
Modern Language Association (MLA)
dos Santos, Adriana Oliveira…[et al.]. Copaiba Oil: An Alternative to Development of New Drugs against Leishmaniasis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-992754
American Medical Association (AMA)
dos Santos, Adriana Oliveira& Ueda-Nakamura, Tânia& Dias Filho, Benedito Prado& Veiga-Junior, Valdir F.& Nakamura, Celso Vataru. Copaiba Oil: An Alternative to Development of New Drugs against Leishmaniasis. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992754