Copaiba Oil-Resin Treatment Is Neuroprotective and Reduces Neutrophil Recruitment and Microglia Activation after Motor Cortex Excitotoxic Injury
Joint Authors
Guimarães-Santos, Adriano
Santos, Diego Siqueira
Santos, Ijair Rogério
Lima, Rafael Rodrigues
Pereira, Antonio
de Moura, Lucinewton Silva
Carvalho, Raul Nunes
Lameira, Osmar
Gomes-Leal, Walace
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The oil-resin of Copaifera reticulata Ducke is used in the Brazilian folk medicine as an anti-inflammatory and healing agent.
However, there are no investigations on the possible anti-inflammatory and neuroprotective roles of copaiba oil-resin (COR) after neural disorders.
We have investigated the anti-inflammatory and neuroprotective effects of COR following an acute damage to the motor cortex of adult rats.
Animals were injected with the neurotoxin N-Methyl-D-Aspartate (NMDA) (n=10) and treated with a single dose of COR (400 mg/kg, i.p.) soon after surgery (Group 1) or with two daily doses (200 mg/kg, i.p.) during 3 days (Group 2) alter injury.
Control animals were treated with vehicle only.
COR treatment induced tissue preservation and decreased the recruitment of neutrophils and microglial activation in the injury site compared to vehicle animals.
The results suggest that COR treatment induces neuroprotection by modulating inflammatory response following an acute damage to the central nervous system.
American Psychological Association (APA)
Guimarães-Santos, Adriano& Santos, Diego Siqueira& Santos, Ijair Rogério& Lima, Rafael Rodrigues& Pereira, Antonio& de Moura, Lucinewton Silva…[et al.]. 2012. Copaiba Oil-Resin Treatment Is Neuroprotective and Reduces Neutrophil Recruitment and Microglia Activation after Motor Cortex Excitotoxic Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992769
Modern Language Association (MLA)
Guimarães-Santos, Adriano…[et al.]. Copaiba Oil-Resin Treatment Is Neuroprotective and Reduces Neutrophil Recruitment and Microglia Activation after Motor Cortex Excitotoxic Injury. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-992769
American Medical Association (AMA)
Guimarães-Santos, Adriano& Santos, Diego Siqueira& Santos, Ijair Rogério& Lima, Rafael Rodrigues& Pereira, Antonio& de Moura, Lucinewton Silva…[et al.]. Copaiba Oil-Resin Treatment Is Neuroprotective and Reduces Neutrophil Recruitment and Microglia Activation after Motor Cortex Excitotoxic Injury. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992769
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992769