Effect of Quercetin in the 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-Induced Mouse Model of Parkinson's Disease
Joint Authors
Lv, Chuanfeng
Hong, Tie
Yang, Zhen
Zhang, Yu
Wang, Lu
Dong, Man
Zhao, Jing
Mu, Jiaye
Meng, Yixiao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In this paper, the protective effect of the bioflavonoid quercetin on behaviors, antioxidases, and neurotransmitters in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-(MPTP-) induced Parkinson's disease (PD) was investigated.
Quercetin treatment (50 mg/kg, 100 mg/kg and 200 mg/kg body weight) was orally administered for 14 consecutive days.
The results show that quercetin treatment markedly improves the motor balance and coordination of MPTP-treated mice.
Significant increases were observed in the activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), and Na+, K+-ATPase, AchE, the content of dopamine (DA) in the quercetin plus MPTP groups compared to those in the MPTP group.
Significant reduction the 4-hydroxy-2-nonenal (4-HNE) immunoreactivity in striatum of brains was observed in the quercetin plus MPTP groups in comparison to the MPTP group.
Taken together, we propose that quercetin has shown antiparkinsonian properties in our studies.
More work is needed to explore detailed mechanisms of action.
American Psychological Association (APA)
Lv, Chuanfeng& Hong, Tie& Yang, Zhen& Zhang, Yu& Wang, Lu& Dong, Man…[et al.]. 2012. Effect of Quercetin in the 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-Induced Mouse Model of Parkinson's Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-992783
Modern Language Association (MLA)
Lv, Chuanfeng…[et al.]. Effect of Quercetin in the 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-Induced Mouse Model of Parkinson's Disease. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-992783
American Medical Association (AMA)
Lv, Chuanfeng& Hong, Tie& Yang, Zhen& Zhang, Yu& Wang, Lu& Dong, Man…[et al.]. Effect of Quercetin in the 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-Induced Mouse Model of Parkinson's Disease. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-992783
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992783