Zerumbone, a Southeast Asian Ginger Sesquiterpene, Induced Apoptosis of Pancreatic Carcinoma Cells through p53 Signaling Pathway
Joint Authors
Zhang, Songyan
Liu, Qiaojing
Liu, Yanju
Qiao, Hong
Liu, Yu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Pancreatic carcinoma is one common cancer with gradually increasing incidence during the past several decades.
However, currently the candidate drugs to suppress pancreatic cancer remain lacking.
This research was carried out to investigate if zerumbone, a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith, will produce the anticancer effects on pancreatic carcinoma cell lines.
The results showed that zerumbone concentration, and time, dependently produced inhibitory actions on cell viability of PANC-1 cells.
In addition, Hoechst 33342, AO/EB, TUNEL staining, and caspase-3 activity assay further showed that zerumbone induced apoptosis of PANC-1 cells.
The expression of p53 protein was markedly upregulated, and the p21 level was also obviously elevated in zerumbone-treated PANC-1 cells.
Moreover, ROS production was increased by about 149% in PANC-1 cells treated by zerumbone 30 μM.
Zerumbone also produced the same antitumor activity in pancreatic carcinoma cell lines SW1990 and AsPC-1.
In summary, we found that zerumbone was able to induce apoptosis of pancreatic carcinoma cell lines, indicating to be a promising treatment for pancreatic cancer.
American Psychological Association (APA)
Zhang, Songyan& Liu, Qiaojing& Liu, Yanju& Qiao, Hong& Liu, Yu. 2012. Zerumbone, a Southeast Asian Ginger Sesquiterpene, Induced Apoptosis of Pancreatic Carcinoma Cells through p53 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992795
Modern Language Association (MLA)
Zhang, Songyan…[et al.]. Zerumbone, a Southeast Asian Ginger Sesquiterpene, Induced Apoptosis of Pancreatic Carcinoma Cells through p53 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992795
American Medical Association (AMA)
Zhang, Songyan& Liu, Qiaojing& Liu, Yanju& Qiao, Hong& Liu, Yu. Zerumbone, a Southeast Asian Ginger Sesquiterpene, Induced Apoptosis of Pancreatic Carcinoma Cells through p53 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992795