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Antidepressant-Like Effects of Shuyusan in Rats Exposed to Chronic Stress: Effects on Hypothalamic-Pituitary-Adrenal Function
Joint Authors
Chen, Liping
Chen, Mengli
Wang, Fawei
Sun, Zhigao
Quanzhi, Huang
Geng, Miao
Chen, Hongyan
Duan, Dongmei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study was to investigate antidepressant activities of Shuyusan (a Chinese herb), using a rats model of depression induced by unpredictable chronic mild stress (UCMS).
The administration groups were treated with Shuyusan decoction for 3 weeks and compared with fluoxetine treatment.
In order to understand the potential antidepressant-like activities of Shuyusan, tail suspension test (TST) and forced swimming test (FST) were used as behavioral despair study.
The level of corticotropin-releasing factor (CRH), adrenocorticotropic hormone (ACTH), corticosterone (CORT) and hippocampus glucocorticoid receptor expression were examined.
After modeling, there was a significant prolongation of immobility time in administration groups with the TST and FST.
High-dose Shuyusan could reduce the immobility time measured with the TST and FST.
The immobility time in high-dose herbs group and fluoxetine group was increased significantly compared with the model group.
After 3 weeks herbs fed, the serum contents level of CRH, ACTH, and CORT in high-dose herb group was significantly decreased compared to the model group.
The result indicated that Shuyusan had antidepressant activity effects on UCMS model rats.
The potential antidepressant effect may be related to decreasing glucocorticoid levels activity, regulating the function of HPA axis, and inhibiting glucocorticoid receptor expression in hippocampus.
American Psychological Association (APA)
Chen, Liping& Chen, Mengli& Wang, Fawei& Sun, Zhigao& Quanzhi, Huang& Geng, Miao…[et al.]. 2012. Antidepressant-Like Effects of Shuyusan in Rats Exposed to Chronic Stress: Effects on Hypothalamic-Pituitary-Adrenal Function. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992799
Modern Language Association (MLA)
Chen, Liping…[et al.]. Antidepressant-Like Effects of Shuyusan in Rats Exposed to Chronic Stress: Effects on Hypothalamic-Pituitary-Adrenal Function. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-992799
American Medical Association (AMA)
Chen, Liping& Chen, Mengli& Wang, Fawei& Sun, Zhigao& Quanzhi, Huang& Geng, Miao…[et al.]. Antidepressant-Like Effects of Shuyusan in Rats Exposed to Chronic Stress: Effects on Hypothalamic-Pituitary-Adrenal Function. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992799
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992799