A Dried Yeast Fermentate Prevents and Reduces Inflammation in Two Separate Experimental Immune Models

Abstract EN

Diverse and significant benefits against cold/flu symptoms and seasonal allergies have been observed with a dried fermentate (DF) derived from Saccharomyces cerevisiae (EpiCor) in multiple published randomized trials.

To determine if DF may influence other immune conditions, two separate animal studies were conducted.

Study 1 examined the ability of DF to prevent or reduce inflammation when given orally for 14 days to rats prior to receiving 1% carrageenan (localized inflammation model).

DF significantly (P<0.05) reduced swelling at all time points (1, 2, 3, 6, 12, and 24 hours) versus the control.

Edema severity and PGE2 levels were reduced by approximately 50% and 25% (P<0.05), respectively.

Study 2 examined the ability of DF to treat established inflammation induced by type-2 collagen in mice over 4 weeks (autoimmune arthritis model).

Significantly reduced arthritis scores, antibody response to type-2 collagen, and interferon-gamma levels were observed compared to controls (all parameters P<0.05).

DF favorably impacts multiple acute and potentially chronic immunologic inflammatory control mechanisms and should be further tested in clinical trials.