The Many Faces of Mitochondrial Autophagy: Making Sense of Contrasting Observations in Recent Research
Joint Authors
Devenish, Rodney J.
May, Alexander I.
Prescott, Mark
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-08
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Research into the selective autophagic degradation of mitochondria—mitophagy—has intensified in recent years, yielding significant insights into the function, mechanism, and regulation of this process in the eukaryotic cell.
However, while some molecular players in budding yeast, such as Atg32p, Uth1p, and Aup1p, have been identified, studies further interrogating the mechanistic and regulatory features of mitophagy have yielded inconsistent and sometimes conflicting results.
In this review, we focus on the current understanding of mitophagy mechanism, induction, and regulation in yeast, and suggest that differences in experimental conditions used in the various studies of mitophagy may contribute to the observed discrepancies.
Consideration and understanding of these differences may help place the mechanism and regulation of mitophagy in context, and further indicate the intricate role that this essential process plays in the life and death of eukaryotic cells.
American Psychological Association (APA)
May, Alexander I.& Devenish, Rodney J.& Prescott, Mark. 2012. The Many Faces of Mitochondrial Autophagy: Making Sense of Contrasting Observations in Recent Research. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-992869
Modern Language Association (MLA)
May, Alexander I.…[et al.]. The Many Faces of Mitochondrial Autophagy: Making Sense of Contrasting Observations in Recent Research. International Journal of Cell Biology No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-992869
American Medical Association (AMA)
May, Alexander I.& Devenish, Rodney J.& Prescott, Mark. The Many Faces of Mitochondrial Autophagy: Making Sense of Contrasting Observations in Recent Research. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-992869
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992869