Feature Identification of Compensatory Gene Pairs without Sequence Homology in Yeast
Joint Authors
Peng, Chien-Hua
Tang, Chuan-Yi
Peng, Shih-Chi
Arita, Masanori
Lyu, Ping-Chiang
Lin, Shu-Hsi
Source
International Journal of Genomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Genetic robustness refers to a compensatory mechanism for buffering deleterious mutations or environmental variations.
Gene duplication has been shown to provide such functional backups.
However, the overall contribution of duplication-based buffering for genetic robustness is rather small.
In this study, we investigated whether transcriptional compensation also exists among genes that share similar functions without sequence homology.
A set of nonhomologous synthetic-lethal gene pairs was assessed by using a coexpression network, protein-protein interactions, and other types of genetic interactions in yeast.
Our results are notably different from those of previous studies on buffering paralogs.
The low expression similarity and the conditional coexpression alone do not play roles in identifying the functionally compensatory genes.
Additional properties such as synthetic-lethal interaction, the ratio of shared common interacting partners, and the degree of coregulation were, at least in part, necessary to extract functional compensatory genes.
Our network-based approach is applicable to select several well-documented cases of compensatory gene pairs and a set of new pairs.
The results suggest that transcriptional reprogramming plays a limited role in functional compensation among nonhomologous genes.
Our study aids in understanding the mechanism and features of functional compensation more in detail.
American Psychological Association (APA)
Peng, Chien-Hua& Lin, Shu-Hsi& Peng, Shih-Chi& Lyu, Ping-Chiang& Arita, Masanori& Tang, Chuan-Yi. 2012. Feature Identification of Compensatory Gene Pairs without Sequence Homology in Yeast. International Journal of Genomics،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992911
Modern Language Association (MLA)
Peng, Chien-Hua…[et al.]. Feature Identification of Compensatory Gene Pairs without Sequence Homology in Yeast. International Journal of Genomics No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-992911
American Medical Association (AMA)
Peng, Chien-Hua& Lin, Shu-Hsi& Peng, Shih-Chi& Lyu, Ping-Chiang& Arita, Masanori& Tang, Chuan-Yi. Feature Identification of Compensatory Gene Pairs without Sequence Homology in Yeast. International Journal of Genomics. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992911
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992911