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mRNA 3′ End Processing Factors: A Phylogenetic Comparison
Joint Authors
Lutz, Carol S.
Darmon, Sarah K.
Source
International Journal of Genomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-06
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Almost all eukaryotic mRNAs possess 3′ ends with a polyadenylate (poly(A)) tail.
This poly(A) tail is not encoded in the genome but is added by the process of polyadenylation.
Polyadenylation is a two-step process, and this process is accomplished by multisubunit protein factors.
Here, we comprehensively compare the protein machinery responsible for polyadenylation of mRNAs across many evolutionary divergent species, and we have found these protein factors to be remarkably conserved in nature.
These data suggest that polyadenylation of mRNAs is an ancient process.
American Psychological Association (APA)
Darmon, Sarah K.& Lutz, Carol S.. 2012. mRNA 3′ End Processing Factors: A Phylogenetic Comparison. International Journal of Genomics،Vol. 2012, no. 2012, pp.1-22.
https://search.emarefa.net/detail/BIM-992924
Modern Language Association (MLA)
Darmon, Sarah K.& Lutz, Carol S.. mRNA 3′ End Processing Factors: A Phylogenetic Comparison. International Journal of Genomics No. 2012 (2012), pp.1-22.
https://search.emarefa.net/detail/BIM-992924
American Medical Association (AMA)
Darmon, Sarah K.& Lutz, Carol S.. mRNA 3′ End Processing Factors: A Phylogenetic Comparison. International Journal of Genomics. 2012. Vol. 2012, no. 2012, pp.1-22.
https://search.emarefa.net/detail/BIM-992924
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992924