Optimal Control of a Fed-Batch Fermentation Involving Multiple Feeds

Abstract EN

A nonlinear dynamical system, in which the feed rates of glycerol and alkali are taken as the control functions, is first proposed to formulate the fed-batch culture of 1,3-propanediol (1,3-PD) production.

To maximize the 1,3-PD concentration at the terminal time, a constrained optimal control model is then presented.

A solution approach is developed to seek the optimal feed rates based on control vector parametrization method and improved differential evolution algorithm.

The proposed methodology yielded an increase by 32.17% of 1,3-PD concentration at the terminal time.