Hyperglycemia Increases Muscle Blood Flow and Alters Endothelial Function in Adolescents with Type 1 Diabetes
Joint Authors
Dye, Amanda S.
Bauer, John A.
Huang, Hong
Hoffman, Robert P.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Alterations of blood flow and endothelial function precede development of complications in type 1 diabetes.
The effects of hyperglycemia on vascular function in early type 1 diabetes are poorly understood.
To investigate the effect of hyperglycemia on forearm vascular resistance (FVR) and endothelial function in adolescents with type 1 diabetes, FVR was measured before and after 5 minutes of upper arm arterial occlusion using venous occlusion plethysmography in (1) fasted state, (2) euglycemic state (~90 mg/dL; using 40 mU/m2/min insulin infusion), and (3) hyperglycemic state (~200 mg/dL) in 11 adolescents with type 1 diabetes.
Endothelial function was assessed by the change in FVR following occlusion.
Seven subjects returned for a repeat study with hyperglycemia replaced by euglycemia.
Preocclusion FVR decreased from euglycemia to hyperglycemia (P=0.003).
Postocclusion fall in FVR during hyperglycemia was less than during euglycemia (P=0.002).
These findings were not reproduced when hyperglycemia was replaced with a second euglycemia.
These results demonstrate that acute hyperglycemia causes vasodilation and alters endothelial function in adolescents with type 1 diabetes.
In addition they have implications for future studies of endothelial function in type 1 diabetes and provide insight into the etiology of macrovascular and microvascular complications of type 1 diabetes.
American Psychological Association (APA)
Dye, Amanda S.& Huang, Hong& Bauer, John A.& Hoffman, Robert P.. 2012. Hyperglycemia Increases Muscle Blood Flow and Alters Endothelial Function in Adolescents with Type 1 Diabetes. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-993926
Modern Language Association (MLA)
Dye, Amanda S.…[et al.]. Hyperglycemia Increases Muscle Blood Flow and Alters Endothelial Function in Adolescents with Type 1 Diabetes. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-993926
American Medical Association (AMA)
Dye, Amanda S.& Huang, Hong& Bauer, John A.& Hoffman, Robert P.. Hyperglycemia Increases Muscle Blood Flow and Alters Endothelial Function in Adolescents with Type 1 Diabetes. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-993926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-993926