Propyl Gallate Plays a Nephroprotective Role in Early Stage of Diabetic Nephropathy Associated with Suppression of Glomerular Endothelial Cell Proliferation and Angiogenesis
Joint Authors
Tang, Junming
Li, Junfeng
Shen, Jianming
Liu, Huihui
Tian, Shaojiang
Gan, Yanjie
Wang, Liping
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
There is growing evidence suggesting that glomerular endothelial cell proliferation and angiogenesis may be responsible for the pathophysiological events in the early stage of diabetic nephropathy.
This study was designed to investigate the factors related to glomerular endothelial cell proliferation and glomerular angiogenesis and assess the effect of propyl gallate on preventing these disorders in diabetic rats.
We found that glomerular hypertrophy, glomerular mesangial matrix expansion, and albuminuria were significantly increased in DN rats.
CD31+ endothelial cells significantly increased in glomerulus of diabetic rats.
Double immunofluorescence staining showed some structurally defective vasculus tubes in glomerulus.
Real-time PCR and western blot demonstrated the glomerular eNOS expression remained at the same level, while remarkable decreased NO productions and suppressed eNOS activities were observed in diabetic rats.
Treatment with propyl gallate improved glomerular pathological changes, reduced endothelial cell proliferation, decreased albuminuria, and restored eNOS activity, but did not alter eNOS expression.
These data suggest that endothelial cell proliferation and immature angiogenesis may be the contributors to progression of DN.
Propyl gallate is a potential novel therapeutic agent on prevention of diabetic nephropathy.
American Psychological Association (APA)
Tian, Shaojiang& Tang, Junming& Liu, Huihui& Wang, Liping& Shen, Jianming& Li, Junfeng…[et al.]. 2012. Propyl Gallate Plays a Nephroprotective Role in Early Stage of Diabetic Nephropathy Associated with Suppression of Glomerular Endothelial Cell Proliferation and Angiogenesis. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-993935
Modern Language Association (MLA)
Tian, Shaojiang…[et al.]. Propyl Gallate Plays a Nephroprotective Role in Early Stage of Diabetic Nephropathy Associated with Suppression of Glomerular Endothelial Cell Proliferation and Angiogenesis. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-993935
American Medical Association (AMA)
Tian, Shaojiang& Tang, Junming& Liu, Huihui& Wang, Liping& Shen, Jianming& Li, Junfeng…[et al.]. Propyl Gallate Plays a Nephroprotective Role in Early Stage of Diabetic Nephropathy Associated with Suppression of Glomerular Endothelial Cell Proliferation and Angiogenesis. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-993935
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-993935