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Renal Podocyte Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin
Joint Authors
Kim, Chan-Sik
Sohn, Eunjin
Kim, Junghyun
Kim, Jin Sook
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hyperglycemia promotes oxidative stress and hence generation of reactive oxygen species (ROS), which is known to play a crucial role in the pathogenesis of diabetic nephropathy.
Metformin, an oral hypoglycemic drug, possesses antioxidant effects.
The aim of this paper is to investigate the protective effects of metformin on the injury of renal podocytes in spontaneously diabetic Torii (SDT) rats, a new model for nonobese type 2 diabetes.
Metformin (350 mg/kg/day) was given to SDT rats for 17 weeks.
Blood glucose, glycated haemoglobin (HbA1c), and albuminuria were examined.
Kidney histopathology, renal 8-hydroxydeoxyguanosine (8-OHdG) levels and apoptosis were examined.
In 43-week-old SDT rats, severe hyperglycemia was developed, and albuminuria was markedly increased.
Diabetes induced significant alterations in renal glomerular structure.
In addition, urinary and renal 8-OHdG levels were highly increased, and podocyte loss was shown through application of the TUNEL and synaptopodin staining.
However, treatment of SDT rats with metformin restored all these renal changes.
Our data suggested that diabetes-induced podocyte loss in diabetic nephropathy could be suppressed by the antidiabetes drug, metformin, through the repression of oxidative injury.
American Psychological Association (APA)
Kim, Junghyun& Sohn, Eunjin& Kim, Chan-Sik& Kim, Jin Sook. 2012. Renal Podocyte Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-993936
Modern Language Association (MLA)
Kim, Junghyun…[et al.]. Renal Podocyte Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-993936
American Medical Association (AMA)
Kim, Junghyun& Sohn, Eunjin& Kim, Chan-Sik& Kim, Jin Sook. Renal Podocyte Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-993936
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-993936