Relation of Adiponectin to Glucose Tolerance Status, Adiposity, and Cardiovascular Risk Factor Load
Joint Authors
Wolfson, N.
Gavish, D.
Shargorodsky, M.
Matas, Z.
Boaz, M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Adiponectin has anti-atherogenic and anti-inflammatory properties.
We investigated the influence of adiponectin on glucose tolerance status, adiposity and cardiovascular risk factors (CVRFs).
Design and Patients.
Study consisted of 107 subjects: 55 with normal glucose tolerance (NGT) and 52 with impaired glucose regulation (IGR) who were divided into two groups: 24 subjects with impaired fasting glucose (IFG Group) and 28 patients with type 2 diabetes mellitus (DM Group).
In additional analysis, study participants were divided into two groups, according to CVRFs: low and high risk.
Measurements: Patients were evaluated for glucose, HbA1C, insulin, lipids, CRP, HOMA-IR and adiponectin.
Measurements.
Patients were evaluated for glucose, HbA1C, insulin, lipids, CRP, HOMA-IR and adiponectin.
Results.
Adiponectin was significantly higher in NGT group than in IFG (P=0.003) and DM (P=0.01) groups.
Adiponectin was significantly, positively associated with HDL and inversely associated with glucose, HbA1c, ALT, AST, TG, HOMA-IR.
Patients with higher CVRFs load have lesser adiponectin compared to patients with low cardiovascular risk P<0.0001).
Adiponectin was inversely associated with the number of risk factors (r=−0.430, P=0.0001).
Conclusions.
Circulating adiponectin was significantly lower in subjects with different degree of IGR compared to subjects with normal glucose homeostasis.
Adiponectin was significantly lower in high risk group than low risk group and decreased concurrently with increased number of CVRFs.
American Psychological Association (APA)
Wolfson, N.& Gavish, D.& Matas, Z.& Boaz, M.& Shargorodsky, M.. 2011. Relation of Adiponectin to Glucose Tolerance Status, Adiposity, and Cardiovascular Risk Factor Load. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-993946
Modern Language Association (MLA)
Wolfson, N.…[et al.]. Relation of Adiponectin to Glucose Tolerance Status, Adiposity, and Cardiovascular Risk Factor Load. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-993946
American Medical Association (AMA)
Wolfson, N.& Gavish, D.& Matas, Z.& Boaz, M.& Shargorodsky, M.. Relation of Adiponectin to Glucose Tolerance Status, Adiposity, and Cardiovascular Risk Factor Load. Journal of Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-993946
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-993946