Time-Dependent Alterations in Rat Macrovessels with Type 1 Diabetes
Joint Authors
Loganathan, Rajprasad
VanHoose, Lisa
Stehno-Bittel, Lisa
Fegley, Barbara
Searls, Yvonne
Smirnova, Irina V.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Vascular complications are associated with the progressive severity of diabetes, resulting in significant morbidity and mortality.
This study quantifies functional vascular parameters and macrovascular structure in a rat model of type 1 diabetes.
While there was no difference in the systemic arterial elastance (Ea) with 50 days of diabetes, changes were noted in the aorta and femoral artery including increased tunica media extracellular matrix content, decreased width of both the media and individual smooth muscle cell layers, and increased incidence of damaged mitochondria.
Extracellular matrix proteins and elastin levels were significantly greater in the aorta of diabetic animals.
These differences correlated with diminished matrix metalloprotease activity in the aorta of the diabetic animals.
In conclusion, diabetes significantly altered the structure and ultrastructure of the aorta and femoral artery before systemic changes in arterial elastance could be detected.
American Psychological Association (APA)
Searls, Yvonne& Smirnova, Irina V.& VanHoose, Lisa& Fegley, Barbara& Loganathan, Rajprasad& Stehno-Bittel, Lisa. 2011. Time-Dependent Alterations in Rat Macrovessels with Type 1 Diabetes. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-993961
Modern Language Association (MLA)
Searls, Yvonne…[et al.]. Time-Dependent Alterations in Rat Macrovessels with Type 1 Diabetes. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-993961
American Medical Association (AMA)
Searls, Yvonne& Smirnova, Irina V.& VanHoose, Lisa& Fegley, Barbara& Loganathan, Rajprasad& Stehno-Bittel, Lisa. Time-Dependent Alterations in Rat Macrovessels with Type 1 Diabetes. Journal of Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-993961
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-993961