Adipocytokine Levels in Genetically High Risk for Type 2 Diabetes in the Indian Population: A Cross-Sectional Study
Joint Authors
Gupta, Shachin K.
Vyas, Prerna
Bose, K. Subhash Chandra
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In view of the noteworthy role of adipocytokines in the onset of insulin resistance and diabetes in gene-knockout-rat-model-cell-line studies we aimed to study the influence of genetic predisposition for diabetes on adipocytokine levels and their role in building insulin-resistance-like environment well before the onset of diabetes; thus a hypothesis can be drawn on their role in developing diabetes in high risk population.
Methods.
Ages between 18 and 22 years were selected and divided into three groups.
Group I (n=81): control group with no family history of diabetes.
Group II (n=157): with one of their parents with history of type 2 diabetes.
Group III (n=47): with both parents having history of type 2 diabetes.
In all the groups we estimated fasting plasma glucose, insulin and adipocytokines like adiponectin, leptin, TNF-α, and IL-6.
Results.
Of all adipocytokines we observed significantly lower levels of adiponectin (8.7±1 μg/mL in group III and 9.5±1.3 μg/mL group II) when compared to control (11.0±1.2 μg/mL; P<0.01) and it has strong correlation with family history of diabetes with Pearson’s coefficient of −0.502.
Linear regression analysis showed significant negative association with HOMA-IR (P<0.01) and logistic regression analysis showed highest association with parental diabetes (P<0.01; OR .260, 95% CI .260–.468).
Conclusion.
Genetic predisposition for diabetes may influence adiponectin gene expression leading to decrease in its plasma concentration, which might play a key role in developing diabetes in near future.
American Psychological Association (APA)
Bose, K. Subhash Chandra& Gupta, Shachin K.& Vyas, Prerna. 2012. Adipocytokine Levels in Genetically High Risk for Type 2 Diabetes in the Indian Population: A Cross-Sectional Study. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-993977
Modern Language Association (MLA)
Bose, K. Subhash Chandra…[et al.]. Adipocytokine Levels in Genetically High Risk for Type 2 Diabetes in the Indian Population: A Cross-Sectional Study. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-993977
American Medical Association (AMA)
Bose, K. Subhash Chandra& Gupta, Shachin K.& Vyas, Prerna. Adipocytokine Levels in Genetically High Risk for Type 2 Diabetes in the Indian Population: A Cross-Sectional Study. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-993977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-993977