Dysregulation of Dicer1 in Beta Cells Impairs Islet Architecture and Glucose Metabolism
Joint Authors
Melkman-Zehavi, Tal
Dor, Yuval
Kredo-Russo, Sharon
Oren, Roni
Hornstein, Eran
Mandelbaum, Amitai D.
Nir, Tomer
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
microRNAs (miRNAs) play important roles in pancreas development and in regulation of insulin expression in the adult.
Here we show that loss of miRNAs activity in beta-cells during embryonic development results in lower beta-cell mass and in impaired glucose tolerance.
Dicer1-null cells initially constitute a significant portion of the total beta-cell population.
However, during postnatal development, Dicer1-null cells are depleted.
Furthermore, wild-type beta cells are repopulating the islets in complex compensatory dynamics.
Because loss of Dicer1 is also associated with changes in the distribution of membranous E-cadherin, we hypothesized that E-cadherin activity may play a role in beta cell survival or islet architecture.
However, genetic loss of E-cadherin function does not impair islet architecture, suggesting that miRNAs likely function through other or redundant effectors in the endocrine pancreas.
American Psychological Association (APA)
Mandelbaum, Amitai D.& Melkman-Zehavi, Tal& Oren, Roni& Kredo-Russo, Sharon& Nir, Tomer& Dor, Yuval…[et al.]. 2012. Dysregulation of Dicer1 in Beta Cells Impairs Islet Architecture and Glucose Metabolism. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-993995
Modern Language Association (MLA)
Mandelbaum, Amitai D.…[et al.]. Dysregulation of Dicer1 in Beta Cells Impairs Islet Architecture and Glucose Metabolism. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-993995
American Medical Association (AMA)
Mandelbaum, Amitai D.& Melkman-Zehavi, Tal& Oren, Roni& Kredo-Russo, Sharon& Nir, Tomer& Dor, Yuval…[et al.]. Dysregulation of Dicer1 in Beta Cells Impairs Islet Architecture and Glucose Metabolism. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-993995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-993995