Endothelial Dysfunction in Diabetes Mellitus: Possible Involvement of Endoplasmic Reticulum Stress?
Joint Authors
Ding, Hong
Samuel, Samson Mathews
Basha, Basma
Triggle, Chris R.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The vascular complications of diabetes mellitus impose a huge burden on the management of this disease.
The higher incidence of cardiovascular complications and the unfavorable prognosis among diabetic individuals who develop such complications have been correlated to the hyperglycemia-induced oxidative stress and associated endothelial dysfunction.
Although antioxidants may be considered as effective therapeutic agents to relieve oxidative stress and protect the endothelium, recent clinical trials involving these agents have shown limited therapeutic efficacy in this regard.
In the recent past experimental evidence suggest that endoplasmic reticulum (ER) stress in the endothelial cells might be an important contributor to diabetes-related vascular complications.
The current paper contemplates the possibility of the involvement of ER stress in endothelial dysfunction and diabetes-associated vascular complications.
American Psychological Association (APA)
Basha, Basma& Samuel, Samson Mathews& Triggle, Chris R.& Ding, Hong. 2012. Endothelial Dysfunction in Diabetes Mellitus: Possible Involvement of Endoplasmic Reticulum Stress?. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-994001
Modern Language Association (MLA)
Basha, Basma…[et al.]. Endothelial Dysfunction in Diabetes Mellitus: Possible Involvement of Endoplasmic Reticulum Stress?. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-994001
American Medical Association (AMA)
Basha, Basma& Samuel, Samson Mathews& Triggle, Chris R.& Ding, Hong. Endothelial Dysfunction in Diabetes Mellitus: Possible Involvement of Endoplasmic Reticulum Stress?. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-994001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994001