MicroRNAs in Insulin Resistance and Obesity
Joint Authors
Mitchell, Geraldine M.
Williams, Michael D.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
MicroRNAs (miRNAs) are a class of short, single-stranded non-protein coding gene products which can regulate the gene expression through post-transcriptional inhibition of messenger RNA (mRNA) translation.
They are known to be involved in many essential biological processes including development, insulin secretion, and adipocyte differentiation.
miRNAs are involved in complex metabolic processes, such as energy and lipid metabolism, which have been studied in the context of diabetes and obesity.
Obesity, hyperlipidemia (elevated levels of blood lipids), and insulin resistance are strongly associated with the onset of type 2 diabetes.
These conditions are also associated with aberrant expression of multiple essential miRNAs in pancreatic islets of Langerhans and peripheral tissues, including adipose tissue.
A thorough understanding of the physiological role these miRNAs play in these tissues, and changes to their expression under pathological conditions, will allow researchers to develop new therapeutics with the potential to correct the aberrant expression of miRNAs in type 2 diabetes and obesity.
American Psychological Association (APA)
Williams, Michael D.& Mitchell, Geraldine M.. 2012. MicroRNAs in Insulin Resistance and Obesity. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994003
Modern Language Association (MLA)
Williams, Michael D.& Mitchell, Geraldine M.. MicroRNAs in Insulin Resistance and Obesity. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-994003
American Medical Association (AMA)
Williams, Michael D.& Mitchell, Geraldine M.. MicroRNAs in Insulin Resistance and Obesity. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994003
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994003