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ER Stress and Apoptosis: A New Mechanism for Retinal Cell Death
Joint Authors
Jing, Guangjun
Wang, Joshua J.
Zhang, Sarah X.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The endoplasmic reticulum (ER) is the primary subcellular organelle where proteins are synthesized and folded.
When the homeostasis of the ER is disturbed, unfolded or misfolded proteins accumulate in the ER lumen, resulting in ER stress.
In response to ER stress, cells activate a set of tightly controlled regulatory programs, known as the unfolded protein response (UPR), to restore the normal function of the ER.
However, if ER stress is sustained and the adaptive UPR fails to eliminate unfolded/misfolded proteins, apoptosis will occur to remove the stressed cells.
In recent years, a large body of studies has shown that ER stress-induced apoptosis is implicated in numerous human diseases, such as diabetes and neurogenerative diseases.
Moreover, emerging evidence supports a role of ER stress in retinal apoptosis and cell death in blinding disorders such as age-related macular degeneration and diabetic retinopathy.
In the present review, we summarize recent progress on ER stress and apoptosis in retinal diseases, focusing on various proapoptotic and antiapoptotic pathways that are activated by the UPR, and discuss how these pathways contribute to ER stress-induced apoptosis in retinal cells.
American Psychological Association (APA)
Jing, Guangjun& Wang, Joshua J.& Zhang, Sarah X.. 2011. ER Stress and Apoptosis: A New Mechanism for Retinal Cell Death. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-994027
Modern Language Association (MLA)
Jing, Guangjun…[et al.]. ER Stress and Apoptosis: A New Mechanism for Retinal Cell Death. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-994027
American Medical Association (AMA)
Jing, Guangjun& Wang, Joshua J.& Zhang, Sarah X.. ER Stress and Apoptosis: A New Mechanism for Retinal Cell Death. Journal of Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-994027
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994027