New Experimental Models of Diabetic Nephropathy in Mice Models of Type 2 Diabetes: Efforts to Replicate Human Nephropathy
Joint Authors
Riera, Marta
Batlle, Daniel
Soler, María José
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease.
The use of experimental models of DN has provided valuable information regarding many aspects of DN, including pathophysiology, progression, implicated genes, and new therapeutic strategies.
A large number of mouse models of diabetes have been identified and their kidney disease was characterized to various degrees.
Most experimental models of type 2 DN are helpful in studying early stages of DN, but these models have not been able to reproduce the characteristic features of more advanced DN in humans such as nodules in the glomerular tuft or glomerulosclerosis.
The generation of new experimental models of DN created by crossing, knockdown, or knockin of genes continues to provide improved tools for studying DN.
These models provide an opportunity to search for new mechanisms involving the development of DN, but their shortcomings should be recognized as well.
Moreover, it is important to recognize that the genetic background has a substantial effect on the susceptibility to diabetes and kidney disease development in the various models of diabetes.
American Psychological Association (APA)
Soler, María José& Riera, Marta& Batlle, Daniel. 2012. New Experimental Models of Diabetic Nephropathy in Mice Models of Type 2 Diabetes: Efforts to Replicate Human Nephropathy. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-994030
Modern Language Association (MLA)
Soler, María José…[et al.]. New Experimental Models of Diabetic Nephropathy in Mice Models of Type 2 Diabetes: Efforts to Replicate Human Nephropathy. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-994030
American Medical Association (AMA)
Soler, María José& Riera, Marta& Batlle, Daniel. New Experimental Models of Diabetic Nephropathy in Mice Models of Type 2 Diabetes: Efforts to Replicate Human Nephropathy. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-994030
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994030