Guards and Culprits in the Endoplasmic Reticulum: Glucolipotoxicity and β-Cell Failure in Type II Diabetes
Joint Authors
Kim, Joon-Young
Kim, Han-Jong
Lee, In-Kyu
Karunakaran, Udayakumar
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The endoplasmic reticulum (ER) is a cellular organelle responsible for multiple important cellular functions including the biosynthesis and folding of newly synthesized proteins destined for secretion, such as insulin.
The ER participates in all branches of metabolism, linking nutrient sensing to cellular signaling.
Many pathological and physiological factors perturb ER function and induce ER stress.
ER stress triggers an adaptive signaling cascade, called the unfolded protein response (UPR), to relieve the stress.
The failure of the UPR to resolve ER stress leads to pathological conditions such as β-cell dysfunction and death, and type II diabetes.
However, much less is known about the fine details of the control and regulation of the ER response to hyperglycemia (glucotoxicity), hyperlipidemia (lipotoxicity), and the combination of both (glucolipotoxicity).
This paper considers recent insights into how the response is regulated, which may provide clues into the mechanism of ER stress-mediated β-cell dysfunction and death during the progression of glucolipotoxicity-induced type II diabetes.
American Psychological Association (APA)
Karunakaran, Udayakumar& Kim, Han-Jong& Kim, Joon-Young& Lee, In-Kyu. 2011. Guards and Culprits in the Endoplasmic Reticulum: Glucolipotoxicity and β-Cell Failure in Type II Diabetes. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-994036
Modern Language Association (MLA)
Karunakaran, Udayakumar…[et al.]. Guards and Culprits in the Endoplasmic Reticulum: Glucolipotoxicity and β-Cell Failure in Type II Diabetes. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-994036
American Medical Association (AMA)
Karunakaran, Udayakumar& Kim, Han-Jong& Kim, Joon-Young& Lee, In-Kyu. Guards and Culprits in the Endoplasmic Reticulum: Glucolipotoxicity and β-Cell Failure in Type II Diabetes. Journal of Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-994036
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994036