Cardiac Insulin Resistance and MicroRNA Modulators
Joint Authors
Gul, Rukhsana
Aroor, Annayya R.
Pulakat, Lakshmi
Sowers, James R.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cardiac insulin resistance is a metabolic and functional disorder that is often associated with obesity and/or the cardiorenal metabolic syndrome (CRS), and this disorder may be accentuated by chronic alcohol consumption.
In conditions of over-nutrition, increased insulin (INS) and angiotensin II (Ang II) activate mammalian target for rapamycin (mTOR)/p70 S6 kinase (S6K1) signaling, whereas chronic alcohol consumption inhibits mTOR/S6K1 activation in cardiac tissue.
Although excessive activation of mTOR/S6K1 induces cardiac INS resistance via serine phosphorylation of INS receptor substrates (IRS-1/2), it also renders cardioprotection via increased Ang II receptor 2 (AT2R) upregulation and adaptive hypertrophy.
In the INS-resistant and hyperinsulinemic Zucker obese (ZO) rat, a rodent model for CRS, activation of mTOR/S6K1signaling in cardiac tissue is regulated by protective feed-back mechanisms involving mTOR↔AT2R signaling loop and profile changes of microRNA that target S6K1.
Such regulation may play a role in attenuating progressive heart failure.
Conversely, alcohol-mediated inhibition of mTOR/S6K1, down-regulation of INS receptor and growth-inhibitory mir-200 family, and upregulation of mir-212 that promotes fetal gene program may exacerbate CRS-related cardiomyopathy.
American Psychological Association (APA)
Pulakat, Lakshmi& Aroor, Annayya R.& Gul, Rukhsana& Sowers, James R.. 2011. Cardiac Insulin Resistance and MicroRNA Modulators. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-994043
Modern Language Association (MLA)
Pulakat, Lakshmi…[et al.]. Cardiac Insulin Resistance and MicroRNA Modulators. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-994043
American Medical Association (AMA)
Pulakat, Lakshmi& Aroor, Annayya R.& Gul, Rukhsana& Sowers, James R.. Cardiac Insulin Resistance and MicroRNA Modulators. Journal of Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-994043
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994043