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Mannan-Binding Lectin in Diabetic Kidney Disease: The Impact of Mouse Genetics in a Type 1 Diabetes Model
Joint Authors
Bjerre, Mette
Sharma, Kumar
Thiel, Steffen
Flyvbjerg, Allan
Hansen, Troels Krarup
Nyengaard, Jens Randel
Østergaard, Jakob Appel
RamachandraRao, Satish Posettihalli
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Mannan-binding lectin (MBL) is involved in the development of diabetic nephropathy.
MBL is a part of the innate immune system where it can activate the complement system.
Serum MBL level predicts later renal impairment in diabetes patients.
Direct involvement of MBL in the development of diabetic kidney disease is observed in one animal strain.
However, this involvement may differ among the animal strains.
We thus examined the impact of the genetic background on the role of MBL in diabetic nephropathy.
Materials/Methods.
C57BL/6JBomTac and 129S6/SvEvTac mice were compared.
In both strains, experimental type 1 diabetes was induced in wild-type (WT) and MBL-knockout (MBL-KO) mice by streptozotocin.
Nondiabetic WT and MBL-KO mice were used as controls.
We tested if MBL modified the diabetes-induced kidney changes by two-way ANOVA allowing for interaction.
Results.
MBL aggravated diabetes-induced kidney growth and glomerulus enlargement in C57BL/6JBomTac mice.
MBL did not modify diabetes effects on glomerular basement membrane thickness or mesangial volume in any strain.
Diabetes-induced changes in renal gene transcription of growth factors and matrix components were unaffected by MBL.
Conclusions.
Strain-specific MBL effects were found on downstream diabetic kidney changes.
This emphasizes the importance of genetic background in this model of diabetic complications.
American Psychological Association (APA)
Østergaard, Jakob Appel& Bjerre, Mette& RamachandraRao, Satish Posettihalli& Sharma, Kumar& Nyengaard, Jens Randel& Hansen, Troels Krarup…[et al.]. 2012. Mannan-Binding Lectin in Diabetic Kidney Disease: The Impact of Mouse Genetics in a Type 1 Diabetes Model. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-994050
Modern Language Association (MLA)
Østergaard, Jakob Appel…[et al.]. Mannan-Binding Lectin in Diabetic Kidney Disease: The Impact of Mouse Genetics in a Type 1 Diabetes Model. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-994050
American Medical Association (AMA)
Østergaard, Jakob Appel& Bjerre, Mette& RamachandraRao, Satish Posettihalli& Sharma, Kumar& Nyengaard, Jens Randel& Hansen, Troels Krarup…[et al.]. Mannan-Binding Lectin in Diabetic Kidney Disease: The Impact of Mouse Genetics in a Type 1 Diabetes Model. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-994050
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994050