Angiotensin-Converting Enzyme Genotype and Peripheral Arterial Disease in Diabetic Patients
Joint Authors
Chong, Choon-Khim
Tseng, Farn-Hsuan
Tseng, Ching-Ping
Tseng, Chin-Hsiao
Cheng, Ju-Chien
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We investigated the effect of traditional risk factors (hypertension, dyslipidemia and smoking) on the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and peripheral arterial disease (PAD) in 945 (454 men and 491 women) Taiwanese type 2 diabetic patients with a mean age of 63.5 (SD: 11.4) years.
Among them, 81 (31 men and 50 women) had PAD (ankle-brachial index <0.9).
The adjusted odds ratios (95% confidence intervals) were 2.48 (1.18–5.21), 1.69 (1.00–2.85) and 1.64 (1.12–2.39), respectively, for recessive (DD versus II + ID), dominant (DD + ID versus II) and additive (II = 0, ID = 1 and DD = 2) models.
While analyzing the interaction between DD and the individual risk factor of hypertension, smoking and dyslipidemia, patients with the risk factor and with DD had the highest risk compared to referent patients without the risk factor and with II/ID.
The respective adjusted odds ratios were 5.41 (2.05–14.31), 7.38 (1.87–29.06) and 4.64 (1.70–12.64).
We did not find a significant interaction between DD and any of the risk factors under multiplicative or additive scale.
In conclusion, traditional risk factors (hypertension, smoking and dyslipidemia) play an important role in the association between ACE genotypes and PAD.
Patients with DD genotype and traditional risk factors are at the highest risk.
American Psychological Association (APA)
Tseng, Chin-Hsiao& Tseng, Farn-Hsuan& Chong, Choon-Khim& Tseng, Ching-Ping& Cheng, Ju-Chien. 2011. Angiotensin-Converting Enzyme Genotype and Peripheral Arterial Disease in Diabetic Patients. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994056
Modern Language Association (MLA)
Tseng, Chin-Hsiao…[et al.]. Angiotensin-Converting Enzyme Genotype and Peripheral Arterial Disease in Diabetic Patients. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-994056
American Medical Association (AMA)
Tseng, Chin-Hsiao& Tseng, Farn-Hsuan& Chong, Choon-Khim& Tseng, Ching-Ping& Cheng, Ju-Chien. Angiotensin-Converting Enzyme Genotype and Peripheral Arterial Disease in Diabetic Patients. Journal of Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994056
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994056