Effect of Exercise on Kidney Function, Oxidative Stress, and Inflammation in Type 2 Diabetic KK-Ay Mice
Joint Authors
Yamaguchi, Saori
Murakoshi, Maki
Funabiki, Kazuhiko
Tanimoto, Mitsuo
Tomino, Yasuhiko
Gohda, Tomohito
Furukawa, Masako
Horikoshi, Satoshi
Omote, Keisuke
Ishikawa, Yuji
Hagiwara, Shinji
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Exercise is recommended for the management of type 2 diabetes, but its effects on diabetic nephropathy (DN) are still unknown.
We hypothesized that appropriate exercise improves early DN via attenuation of inflammation and oxidative damage.
Type 2 diabetic KK-Ay mice, a spontaneous DN model, underwent two different kinds of exercise (i.e., moderate and low intensity).
Sedentary mice or those undergoing an exercise regimen causing no significant body weight loss were used.
We examined the urinary excretion of albumin, number of podocytes and macrophages, renal expressions of HIF-1α and MCP-1, and biomarkers of oxidative stress such as urinary 8-OHdG and serum SOD.
Exercise reduced urinary levels of albumin and also maintained the number of podocytes in the exercised KK-Ay mice independently of improvements of overweight and hyperglycemia, although moderate-intensity exercise increased expression of HIF-1α.
Sedentary KK-Ay mice showed increased expression of MCP-1 and infiltration of macrophage, increased urinary 8-OhdG, and decreased serum SOD levels compared with exercised KK-Ay mice.
On the whole, low-intensity exercise attenuates progression of early DN without affecting marked renal ischemia.
Reduction rates of urinary albumin and maintained podocyte numbers, with parallel improvements in oxidative damage and inflammation, are related to beneficial effects of exercise in diabetic kidney disease.
American Psychological Association (APA)
Ishikawa, Yuji& Gohda, Tomohito& Tanimoto, Mitsuo& Omote, Keisuke& Furukawa, Masako& Yamaguchi, Saori…[et al.]. 2012. Effect of Exercise on Kidney Function, Oxidative Stress, and Inflammation in Type 2 Diabetic KK-Ay Mice. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-994058
Modern Language Association (MLA)
Ishikawa, Yuji…[et al.]. Effect of Exercise on Kidney Function, Oxidative Stress, and Inflammation in Type 2 Diabetic KK-Ay Mice. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-994058
American Medical Association (AMA)
Ishikawa, Yuji& Gohda, Tomohito& Tanimoto, Mitsuo& Omote, Keisuke& Furukawa, Masako& Yamaguchi, Saori…[et al.]. Effect of Exercise on Kidney Function, Oxidative Stress, and Inflammation in Type 2 Diabetic KK-Ay Mice. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-994058
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994058