The Common C49620T Polymorphism in the Sulfonylurea Receptor Gene SUR1 (ABCC8) in Patients with Gestational Diabetes and Subsequent Glucose Metabolism Abnormalities
Joint Authors
Majkowska, Lilianna
Safranow, Krzysztof
Homa, Katarzyna
Syrenicz, Anhelli
Molęda, Piotr
Fronczyk, Aneta
Stefański, Adam
Bińczak-Kuleta, Agnieszka
Celewicz, Zbigniew
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
The aim of this study is to investigate the relationship between the common C49620T polymorphism in the sulfonylurea receptor (SUR1) gene and glucose metabolism, β-cell secretory function and insulin resistance in women with a history of gestational diabetes (GDM).
Material and Methods.
Study group included 199 women, diagnosed GDM within the last 5–12 years and control group of comparable 50 women in whom GDM was excluded during pregnancy.
Blood glucose and insulin levels were measured during oral glucose tolerance test.
Indices of insulin resistance (HOMA-IR) and β-cell function (HOMA %B) were calculated.
In all patients, the C49620T polymorphism in intron 15 of the SUR1 gene was determined.
Results.
The distribution of the studied polymorphism in the two groups did not differ from each other (χ2 = 0.34, P=0.8425).
No association between the distribution of polymorphisms and coexisting glucose metabolism disorders (χ2 = 7,13, P=0,3043) was found.
No association was also observed between the polymorphism and HOMA %B or HOMA-IR.
Conclusions.
The polymorphism C49620T in the SUR1 gene is not associated with insulin resistance and/or insulin secretion in women with a history of GDM and does not affect the development of GDM, or the development of glucose intolerance in the studied population.
American Psychological Association (APA)
Molęda, Piotr& Bińczak-Kuleta, Agnieszka& Homa, Katarzyna& Safranow, Krzysztof& Celewicz, Zbigniew& Syrenicz, Anhelli…[et al.]. 2012. The Common C49620T Polymorphism in the Sulfonylurea Receptor Gene SUR1 (ABCC8) in Patients with Gestational Diabetes and Subsequent Glucose Metabolism Abnormalities. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994061
Modern Language Association (MLA)
Molęda, Piotr…[et al.]. The Common C49620T Polymorphism in the Sulfonylurea Receptor Gene SUR1 (ABCC8) in Patients with Gestational Diabetes and Subsequent Glucose Metabolism Abnormalities. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-994061
American Medical Association (AMA)
Molęda, Piotr& Bińczak-Kuleta, Agnieszka& Homa, Katarzyna& Safranow, Krzysztof& Celewicz, Zbigniew& Syrenicz, Anhelli…[et al.]. The Common C49620T Polymorphism in the Sulfonylurea Receptor Gene SUR1 (ABCC8) in Patients with Gestational Diabetes and Subsequent Glucose Metabolism Abnormalities. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994061
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994061