Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Diet-Induced Metabolic Syndrome in Rats
Joint Authors
Brown, Lindsay
Hwang, Sung Hee
Hammock, Bruce D.
Kauter, Kathleen
Iyer, Abishek
Morisseau, Christophe
Alam, Md. Ashraful
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The signs of metabolic syndrome following chronic excessive macronutrient intake include body weight gain, excess visceral adipose deposition, hyperglycaemia, glucose and insulin intolerances, hypertension, dyslipidaemia, endothelial damage, cardiovascular hypertrophy, inflammation, ventricular contractile dysfunction, fibrosis, and fatty liver disease.
Recent studies show increased activity of soluble epoxide hydrolase (sEH) during obesity and metabolic dysfunction.
We have tested whether sEH inhibition has therapeutic potential in a rat model of diet-induced metabolic syndrome.
In these high-carbohydrate, high-fat-fed rats, chronic oral treatment with trans-4-[4-(3-adamantan-1-ylureido)-cyclohexyloxy]-benzoic acid (t-AUCB), a potent sEH inhibitor, alleviated the signs of metabolic syndrome in vivo including glucose, insulin, and lipid abnormalities, changes in pancreatic structure, increased systolic blood pressure, cardiovascular structural and functional abnormalities, and structural and functional changes in the liver.
The present study describes the pharmacological responses to this selective sEH inhibitor in rats with the signs of diet-induced metabolic syndrome.
American Psychological Association (APA)
Iyer, Abishek& Kauter, Kathleen& Alam, Md. Ashraful& Hwang, Sung Hee& Morisseau, Christophe& Hammock, Bruce D.…[et al.]. 2011. Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Diet-Induced Metabolic Syndrome in Rats. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-994082
Modern Language Association (MLA)
Iyer, Abishek…[et al.]. Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Diet-Induced Metabolic Syndrome in Rats. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-994082
American Medical Association (AMA)
Iyer, Abishek& Kauter, Kathleen& Alam, Md. Ashraful& Hwang, Sung Hee& Morisseau, Christophe& Hammock, Bruce D.…[et al.]. Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Diet-Induced Metabolic Syndrome in Rats. Journal of Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-994082
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994082