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Insulin Resistance and Cancer Risk: An Overview of the Pathogenetic Mechanisms
Joint Authors
Brunetti, Antonio
Ventura, Valeria
Foti, Daniela
Nocera, Aurora
Nevolo, Maria T.
Possidente, Katiuscia
Iiritano, Stefania
Arcidiacono, Biagio
Chiefari, Eusebio
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Insulin resistance is common in individuals with obesity or type 2 diabetes (T2D), in which circulating insulin levels are frequently increased.
Recent epidemiological and clinical evidence points to a link between insulin resistance and cancer.
The mechanisms for this association are unknown, but hyperinsulinaemia (a hallmark of insulin resistance) and the increase in bioavailable insulin-like growth factor I (IGF-I) appear to have a role in tumor initiation and progression in insulin-resistant patients.
Insulin and IGF-I inhibit the hepatic synthesis of sex-hormone binding globulin (SHBG), whereas both hormones stimulate the ovarian synthesis of sex steroids, whose effects, in breast epithelium and endometrium, can promote cellular proliferation and inhibit apoptosis.
Furthermore, an increased risk of cancer among insulin-resistant patients can be due to overproduction of reactive oxygen species (ROS) that can damage DNA contributing to mutagenesis and carcinogenesis.
On the other hand, it is possible that the abundance of inflammatory cells in adipose tissue of obese and diabetic patients may promote systemic inflammation which can result in a protumorigenic environment.
Here, we summarize recent progress on insulin resistance and cancer, focusing on various implicated mechanisms that have been described recently, and discuss how these mechanisms may contribute to cancer initiation and progression.
American Psychological Association (APA)
Arcidiacono, Biagio& Iiritano, Stefania& Nocera, Aurora& Possidente, Katiuscia& Nevolo, Maria T.& Ventura, Valeria…[et al.]. 2012. Insulin Resistance and Cancer Risk: An Overview of the Pathogenetic Mechanisms. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-994086
Modern Language Association (MLA)
Arcidiacono, Biagio…[et al.]. Insulin Resistance and Cancer Risk: An Overview of the Pathogenetic Mechanisms. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-994086
American Medical Association (AMA)
Arcidiacono, Biagio& Iiritano, Stefania& Nocera, Aurora& Possidente, Katiuscia& Nevolo, Maria T.& Ventura, Valeria…[et al.]. Insulin Resistance and Cancer Risk: An Overview of the Pathogenetic Mechanisms. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-994086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994086