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Inhibition of Aldose Reductase Activates Hepatic Peroxisome Proliferator-Activated Receptor-α and Ameliorates Hepatosteatosis in Diabetic dbdb Mice
Joint Authors
Xu, Fangui
Zhang, Cuilin
Lin, Jianhui
Liu, Ying
Luo, Yu
Gao, Yuehong
Yang, James Y.
Qiu, Longxin
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We previously demonstrated in streptozotocin-induced diabetic mice that deficiency or inhibition of aldose reductase (AR) caused significant dephosphorylation of hepatic transcriptional factor PPARα, leading to its activation and significant reductions in serum lipid levels.
Herein, we report that inhibition of AR by zopolrestat or by a short-hairpin RNA (shRNA) against AR caused a significant reduction in serum and hepatic triglycerides levels in 10-week old diabetic db/db mice.
Meanwhile, hyperglycemia-induced phosphorylation of hepatic ERK1/2 and PPARα was significantly attenuated in db/db mice treated with zopolrestat or AR shRNA.
Further, in comparison with the untreated db/db mice, the hepatic mRNA expression of Aco and ApoA5, two target genes for PPARα, was increased by 93% (P<0.05) and 73% (P<0.05) in zopolrestat-treated mice, respectively.
Together, these data indicate that inhibition of AR might lead to significant amelioration in hyperglycemia-induced dyslipidemia and nonalcoholic fatty liver disease.
American Psychological Association (APA)
Qiu, Longxin& Lin, Jianhui& Xu, Fangui& Gao, Yuehong& Zhang, Cuilin& Liu, Ying…[et al.]. 2011. Inhibition of Aldose Reductase Activates Hepatic Peroxisome Proliferator-Activated Receptor-α and Ameliorates Hepatosteatosis in Diabetic dbdb Mice. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994088
Modern Language Association (MLA)
Qiu, Longxin…[et al.]. Inhibition of Aldose Reductase Activates Hepatic Peroxisome Proliferator-Activated Receptor-α and Ameliorates Hepatosteatosis in Diabetic dbdb Mice. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-994088
American Medical Association (AMA)
Qiu, Longxin& Lin, Jianhui& Xu, Fangui& Gao, Yuehong& Zhang, Cuilin& Liu, Ying…[et al.]. Inhibition of Aldose Reductase Activates Hepatic Peroxisome Proliferator-Activated Receptor-α and Ameliorates Hepatosteatosis in Diabetic dbdb Mice. Journal of Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994088
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994088