Association of FTO Polymorphisms with Early Age of Obesity in Obese Italian Subjects
Joint Authors
Incani, Michela
Cossu, Efisio
Coccia, Federica
Leonetti, Frida
Romeo, Stefano
Cambuli, Valentina Maria
Baroni, Marco G.
Sentinelli, Federica
Cavallo, Maria Gisella
Capoccia, Danila
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Obesity is recognized as a major health problem worldwide.
Genetic factors play a major role in obesity, and genomewide association studies have provided evidence that several common variants within the fat mass- and obesity-associated (FTO) gene are significantly associated with obesity.
Very limited data is available on FTO in the Italian population.
Aims of our study are to investigate: (1) the association of FTO gene SNPs rs9939609 and rs9930506 with body mass index (BMI) and obesity-related parameters in a large cohort (n=752) of Italian obese subjects; (2) the association between the two FTO SNPs and age of onset of obesity.
Our results demonstrate a strong association between FTO SNPs rs9939609 (P<0.043) and rs9930506 (P<0.029) with BMI in the Italian population.
FTO rs9930506 was significantly associated with higher BMI in a G allele dose-dependent manner (BMI+1.4 kg/m2 per G allele).
We also observed that the association with BMI of the two FTO variants varied with age, with the carriers of the risk alleles developing an increase in body weight earlier in life.
In conclusion, our study further demonstrates a role of the genetic variability in FTO on BMI in a large Italian population.
American Psychological Association (APA)
Sentinelli, Federica& Incani, Michela& Coccia, Federica& Capoccia, Danila& Cambuli, Valentina Maria& Romeo, Stefano…[et al.]. 2012. Association of FTO Polymorphisms with Early Age of Obesity in Obese Italian Subjects. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994112
Modern Language Association (MLA)
Sentinelli, Federica…[et al.]. Association of FTO Polymorphisms with Early Age of Obesity in Obese Italian Subjects. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-994112
American Medical Association (AMA)
Sentinelli, Federica& Incani, Michela& Coccia, Federica& Capoccia, Danila& Cambuli, Valentina Maria& Romeo, Stefano…[et al.]. Association of FTO Polymorphisms with Early Age of Obesity in Obese Italian Subjects. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994112