Common Variants of Homocysteine Metabolism Pathway Genes and Risk of Type 2 Diabetes and Related Traits in Indians
Joint Authors
Kaur, Ismeet
Dwivedi, Om Prakash
Tandon, Nikhil
Tabassum, Rubina
Bharadwaj, Dwaipayan
Chauhan, Ganesh
Ghosh, Saurabh
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Hyperhomocysteinemia, a risk factor for cardiovascular disorder, obesity, and type 2 diabetes, is prevalent among Indians who are at high risk of these metabolic disorders.
We evaluated association of common variants of genes involved in homocysteine metabolism or its levels with type 2 diabetes, obesity, and related traits in North Indians.
We genotyped 90 variants in initial phase (2.115 subjects) and replicated top signals in an independent sample set (2.085 subjects).
The variant MTHFR-rs1801133 was the top signal for association with type 2 diabetes (OR=0.78 (95% CI=0.67–0.92), P=0.003) and was also associated with 2 h postload plasma glucose (P=0.04), high-density lipoprotein cholesterol (P=0.004), and total cholesterol (P=0.01) in control subjects.
These associations were neither replicated nor significant after meta-analysis.
Studies involving a larger study population and different ethnic groups are required before ruling out the role of these important candidate genes in type 2 diabetes, obesity, and related traits.
American Psychological Association (APA)
Chauhan, Ganesh& Kaur, Ismeet& Tabassum, Rubina& Dwivedi, Om Prakash& Ghosh, Saurabh& Tandon, Nikhil…[et al.]. 2011. Common Variants of Homocysteine Metabolism Pathway Genes and Risk of Type 2 Diabetes and Related Traits in Indians. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994133
Modern Language Association (MLA)
Chauhan, Ganesh…[et al.]. Common Variants of Homocysteine Metabolism Pathway Genes and Risk of Type 2 Diabetes and Related Traits in Indians. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-994133
American Medical Association (AMA)
Chauhan, Ganesh& Kaur, Ismeet& Tabassum, Rubina& Dwivedi, Om Prakash& Ghosh, Saurabh& Tandon, Nikhil…[et al.]. Common Variants of Homocysteine Metabolism Pathway Genes and Risk of Type 2 Diabetes and Related Traits in Indians. Journal of Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994133
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994133