ADRB3 Polymorphism Associated with BMI Gain in Japanese Men
Joint Authors
Katoh, Takahiko
Kuroda, Yoshiki
Yamauchi, Takenori
Takeuchi, Shouhei
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of this study was to evaluate the association between the Trp64Arg polymorphism in the beta3-adrenergic receptor gene (ADRB3: rs4994) and BMI and serological and anthropometric data in healthy Japanese.
Methods.
Healthy Japanese recruited in a large-scale integrated manufacturing facility in Japan (N=1355; age: 37.25 ± 9.43; BMI: 22.86 ± 3.46) were eligible for analysis.
The anthropometric data and serological data were measured during a comprehensive health check, and a self-reporting questionnaire was used to assess lifestyle habits (current exercise, smoking status, alcohol intake, and working style) and weight at age 20.
Genotyping for the ADRB3 polymorphism was performed by PCR-RFLP method.
Results.
Among 1355 participants, the genotype frequencies of the Trp/Trp, Trp/Arg, and Arg/Arg variants were 920 (67.9%), 394 (29.1%), and 41 (3.05%), respectively.
In the multivariate analysis, a multiple linear regression model in men for the adjustment of age, drinking habits, smoking habits, exercise habits, working status and serological measurements statistically showed an overall weak significance between annual BMI gain from age 20 and age, LDL or ADRB3 polymorphism.
Conclusions.
The level of LDL, age, and ADRB3 polymorphism (Arg/Arg genotype) were statistically associated with annual BMI gain in Japanese men.
American Psychological Association (APA)
Takeuchi, Shouhei& Katoh, Takahiko& Yamauchi, Takenori& Kuroda, Yoshiki. 2012. ADRB3 Polymorphism Associated with BMI Gain in Japanese Men. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-994136
Modern Language Association (MLA)
Takeuchi, Shouhei…[et al.]. ADRB3 Polymorphism Associated with BMI Gain in Japanese Men. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-994136
American Medical Association (AMA)
Takeuchi, Shouhei& Katoh, Takahiko& Yamauchi, Takenori& Kuroda, Yoshiki. ADRB3 Polymorphism Associated with BMI Gain in Japanese Men. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-994136
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994136