Haplotypes in the CRP Gene Associated with Increased BMI and Levels of CRP in Subjects with Type 2 Diabetes or Obesity from Southwestern Mexico
Joint Authors
Flores-Alfaro, Eugenia
Parra-Rojas, Isela
Leyva-Vázquez, Marco A.
Vences-Velázquez, Amalia
Cruz, Miguel
Fernández-Tilapa, Gloria
Muñoz-Valle, José Francisco
Quiróz-Vargas, Irma
Martínez-Calleja, América
Salazar-Martínez, Eduardo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We evaluated the association between four polymorphisms in the CRP gene with circulating levels of C-reactive protein (CRP), type 2 diabetes (T2D), obesity, and risk score of coronary heart disease.
Methods.
We studied 402 individuals and classified them into four groups: healthy, obese, T2D obese, and T2D without obesity, from Guerrero, Southwestern Mexico.
Blood levels of CRP, glucose, cholesterol, triglycerides, and leukocytes were measured.
Genotyping was performed by PCR/RFLP, and the risk score for coronary heart disease was determined by the Framingham's methodology.
Results.
The TT genotype of SNP rs1130864 was associated with increased body mass index and T2D patients with obesity.
We found that the haplotype 2 (TGAG) was associated with increased levels of CRP (β=0.3; 95%CI: 0.1, 0.5; P=0.005) and haplotype 7 (TGGG) with higher body mass index (BMI) (β=0.2; 95%CI: 0.1, 0.3; P<0.001).
The risk score for coronary heart disease was associated with increased levels of CRP, but not with any polymorphism or haplotype.
Conclusions.
The association between the TT genotype of SNP rs1130864 with obesity and the haplotype 7 with BMI may explain how obesity and genetic predisposition increase the risk of diseases such as T2D in the population of Southwestern Mexico.
American Psychological Association (APA)
Martínez-Calleja, América& Quiróz-Vargas, Irma& Parra-Rojas, Isela& Muñoz-Valle, José Francisco& Leyva-Vázquez, Marco A.& Fernández-Tilapa, Gloria…[et al.]. 2012. Haplotypes in the CRP Gene Associated with Increased BMI and Levels of CRP in Subjects with Type 2 Diabetes or Obesity from Southwestern Mexico. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994137
Modern Language Association (MLA)
Martínez-Calleja, América…[et al.]. Haplotypes in the CRP Gene Associated with Increased BMI and Levels of CRP in Subjects with Type 2 Diabetes or Obesity from Southwestern Mexico. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-994137
American Medical Association (AMA)
Martínez-Calleja, América& Quiróz-Vargas, Irma& Parra-Rojas, Isela& Muñoz-Valle, José Francisco& Leyva-Vázquez, Marco A.& Fernández-Tilapa, Gloria…[et al.]. Haplotypes in the CRP Gene Associated with Increased BMI and Levels of CRP in Subjects with Type 2 Diabetes or Obesity from Southwestern Mexico. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994137
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994137