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The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria?
Joint Authors
Silva Miranda, Mayra
Breiman, Adrien
Allain, Sophie
Deknuydt, Florence
Altare, Frederic
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
One of the main features of the immune response to M.
Tuberculosis is the formation of an organized structure called granuloma.
It consists mainly in the recruitment at the infectious stage of macrophages, highly differentiated cells such as multinucleated giant cells, epithelioid cells and Foamy cells, all these cells being surrounded by a rim of lymphocytes.
Although in the first instance the granuloma acts to constrain the infection, some bacilli can actually survive inside these structures for a long time in a dormant state.
For some reasons, which are still unclear, the bacilli will reactivate in 10% of the latently infected individuals, escape the granuloma and spread throughout the body, thus giving rise to clinical disease, and are finally disseminated throughout the environment.
In this review we examine the process leading to the formation of the granulomatous structures and the different cell types that have been shown to be part of this inflammatory reaction.
We also discuss the different in vivo and in vitro models available to study this fascinating immune structure.
American Psychological Association (APA)
Silva Miranda, Mayra& Breiman, Adrien& Allain, Sophie& Deknuydt, Florence& Altare, Frederic. 2012. The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria?. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-994339
Modern Language Association (MLA)
Silva Miranda, Mayra…[et al.]. The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria?. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-994339
American Medical Association (AMA)
Silva Miranda, Mayra& Breiman, Adrien& Allain, Sophie& Deknuydt, Florence& Altare, Frederic. The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria?. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-994339
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994339