The Effect of Specific Immunotherapy on Natural Killer T cells in Peripheral Blood of House Dust Mite-Sensitized Children with Asthma
Joint Authors
Wei, Chen
Chen, Li
Lan-fang, Cao
Yan-ming, Lu
Ya-qin, Li
Wen-ming, Zhang
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
To investigate the effects of specific immunotherapy on the NKT cells in peripheral blood and the ability of NKT cells to proliferate in response to alpha-galactosylceramide (alpha-GalCer) in house-dust-mite- (HDM-) sensitized asthma children, peripheral blood mononuclear cells were isolated from 42 asthmatic children, of whom 24 were on specific immunotherapy (SIT) for more than a year and 20 were healthy.
Compared with control group, the ratio of peripheral blood NKT and CD4+NKT cells was significantly decreased (P<0.01) and was elevated in SIT asthma group (P<0.05), respectively, but it was still less than the normal control group (P<0.01).
The level of IL-4 in serum secreted by NKT cells in asthma group was significantly higher than that of control group (P<0.01), particularly apparent after 72 hours.
The level of IL-4 in SIT group decreased significantly (P<0.01).
The level of IL-10 in serum secreted by NKT cells in asthma group was decreased significantly than that of the control group (P<0.01) especially in 48 hours, while that of SIT group was increased significantly (P<0.01).
These results suggest that the pathogenesis of asthma may be related to the ratio and dysfunction of NKT and CD4+NKT cells.
American Psychological Association (APA)
Yan-ming, Lu& Lan-fang, Cao& Chen, Li& Ya-qin, Li& Wei, Chen& Wen-ming, Zhang. 2012. The Effect of Specific Immunotherapy on Natural Killer T cells in Peripheral Blood of House Dust Mite-Sensitized Children with Asthma. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-994342
Modern Language Association (MLA)
Yan-ming, Lu…[et al.]. The Effect of Specific Immunotherapy on Natural Killer T cells in Peripheral Blood of House Dust Mite-Sensitized Children with Asthma. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-994342
American Medical Association (AMA)
Yan-ming, Lu& Lan-fang, Cao& Chen, Li& Ya-qin, Li& Wei, Chen& Wen-ming, Zhang. The Effect of Specific Immunotherapy on Natural Killer T cells in Peripheral Blood of House Dust Mite-Sensitized Children with Asthma. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-994342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994342