The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to Maternal ABO Genotypes
Joint Authors
Skogen, Bjørn
Killie, Mette Kjær
Husebekk, Anne
Ahlen, Maria Therese
Olsson, Martin L.
Kjeldsen-Kragh, Jens
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Maternal alloantibodies against HPA-1a can cross placenta, opsonize foetal platelets, and induce neonatal alloimmune thrombocytopenia (NAIT).
In a study of 100, 448 pregnant women in Norway during 1995–2004, 10.6% of HPA-1a negative women had detectable anti-HPA-1a antibodies.
Design and Methods.
A possible correlation between the maternal ABO blood group phenotype, or underlying genotype, and severe thrombocytopenia in the newborn was investigated.
Results.
We observed that immunized women with blood group O had a lower risk of having a child with severe NAIT than women with group A; 20% with blood group O gave birth to children with severe NAIT, compared to 47% among the blood group A mothers (relative risk 0.43; 95% CI 0.25–0.75).
Conclusion.
The risk of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO types, and this study indicates that the observation is due to genetic properties on the maternal side.
American Psychological Association (APA)
Ahlen, Maria Therese& Husebekk, Anne& Killie, Mette Kjær& Kjeldsen-Kragh, Jens& Olsson, Martin L.& Skogen, Bjørn. 2011. The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to Maternal ABO Genotypes. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-994346
Modern Language Association (MLA)
Ahlen, Maria Therese…[et al.]. The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to Maternal ABO Genotypes. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-994346
American Medical Association (AMA)
Ahlen, Maria Therese& Husebekk, Anne& Killie, Mette Kjær& Kjeldsen-Kragh, Jens& Olsson, Martin L.& Skogen, Bjørn. The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to Maternal ABO Genotypes. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-994346
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994346